Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 172 (13 Nov 2019)
Sequence version 2 (23 Jan 2007)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Histone H4

Gene

H4c1

more
Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi17 – 215

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-110330 Recognition and association of DNA glycosylase with site containing an affected purine
R-MMU-110331 Cleavage of the damaged purine
R-MMU-171306 Packaging Of Telomere Ends
R-MMU-201722 Formation of the beta-catenin:TCF transactivating complex
R-MMU-212300 PRC2 methylates histones and DNA
R-MMU-2299718 Condensation of Prophase Chromosomes
R-MMU-2559580 Oxidative Stress Induced Senescence
R-MMU-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-MMU-2559586 DNA Damage/Telomere Stress Induced Senescence
R-MMU-3214841 PKMTs methylate histone lysines
R-MMU-3214842 HDMs demethylate histones
R-MMU-3214847 HATs acetylate histones
R-MMU-3214858 RMTs methylate histone arginines
R-MMU-427359 SIRT1 negatively regulates rRNA expression
R-MMU-427413 NoRC negatively regulates rRNA expression
R-MMU-4551638 SUMOylation of chromatin organization proteins
R-MMU-5250924 B-WICH complex positively regulates rRNA expression
R-MMU-5578749 Transcriptional regulation by small RNAs
R-MMU-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-MMU-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-MMU-5693571 Nonhomologous End-Joining (NHEJ)
R-MMU-5693607 Processing of DNA double-strand break ends
R-MMU-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-MMU-69473 G2/M DNA damage checkpoint
R-MMU-73728 RNA Polymerase I Promoter Opening
R-MMU-73772 RNA Polymerase I Promoter Escape
R-MMU-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-MMU-9018519 Estrogen-dependent gene expression

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone H4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:H4c1
Synonyms:Hist1h4a
AND
Name:H4c2
Synonyms:H4-53, Hist1h4b
AND
Name:H4c3
Synonyms:H4-12, Hist1h4c
AND
Name:H4c4
Synonyms:Hist1h4d
AND
Name:H4c6
Synonyms:Hist1h4f
AND
Name:H4c8
Synonyms:Hist1h4h
AND
Name:H4c9
Synonyms:Hist1h4i
AND
Name:H4c11
Synonyms:Hist1h4j
AND
Name:H4c12
Synonyms:Hist1h4k
AND
AND
Name:H4c14
Synonyms:Hist2h4, Hist2h4a
AND
Name:H4f16
Synonyms:Hist4h4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 13, Chromosome 3, Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2448419 H4c1
MGI:2448436 H4c11
MGI:2448439 H4c12
MGI:2140113 H4c14
MGI:2448420 H4c2
MGI:2448421 H4c3
MGI:2448423 H4c4
MGI:2448425 H4c6
MGI:2448427 H4c8
MGI:2448432 H4c9
MGI:2448443 H4f16
MGI:2448441 Hist1h4m

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001583292 – 103Histone H4Add BLAST102

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineBy similarity1
Modified residuei2Phosphoserine1 Publication1
Modified residuei4Asymmetric dimethylarginine; by PRMT1; alternate1 Publication1
Modified residuei4Citrulline; alternateBy similarity1
Modified residuei4Omega-N-methylarginine; by PRMT1; alternateBy similarity1
Modified residuei4Symmetric dimethylarginine; by PRMT5 and PRMT7; alternate1 Publication1
Modified residuei6N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei6N6-(beta-hydroxybutyryl)lysine; alternate1 Publication1
Modified residuei6N6-acetyllysine; alternateCombined sources1
Modified residuei6N6-butyryllysine; alternate1 Publication1
Modified residuei6N6-crotonyllysine; alternate1 Publication1
Modified residuei6N6-glutaryllysine; alternateBy similarity1
Modified residuei9N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei9N6-(beta-hydroxybutyryl)lysine; alternate1 Publication1
Modified residuei9N6-acetyllysine; alternateCombined sources1
Modified residuei9N6-butyryllysine; alternate1 Publication1
Modified residuei9N6-crotonyllysine; alternate1 Publication1
Modified residuei9N6-propionyllysine; alternateBy similarity1
Modified residuei13N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei13N6-(beta-hydroxybutyryl)lysine; alternate1 Publication1
Modified residuei13N6-acetyllysine; alternateCombined sources1
Modified residuei13N6-butyryllysine; alternate1 Publication1
Modified residuei13N6-crotonyllysine; alternateBy similarity1
Modified residuei13N6-glutaryllysine; alternateBy similarity1
Modified residuei13N6-succinyllysine; alternateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki13Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei17N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei17N6-acetyllysine; alternateCombined sources1
Modified residuei17N6-butyryllysine; alternateBy similarity1
Modified residuei17N6-crotonyllysine; alternate1 Publication1
Modified residuei17N6-propionyllysine; alternateBy similarity1
Modified residuei21N6,N6,N6-trimethyllysine; alternate1 Publication1
Modified residuei21N6,N6-dimethyllysine; alternateBy similarity1
Modified residuei21N6-methyllysine; alternateBy similarity1
Cross-linki21Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei32N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei32N6-acetyllysine; alternateCombined sources1
Modified residuei32N6-butyryllysine; alternateBy similarity1
Modified residuei32N6-glutaryllysine; alternateBy similarity1
Modified residuei32N6-propionyllysine; alternateBy similarity1
Modified residuei32N6-succinyllysine; alternate1 Publication1
Cross-linki32Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei45N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei45N6-butyryllysine; alternateBy similarity1
Modified residuei45N6-propionyllysine; alternateBy similarity1
Modified residuei48PhosphoserineCombined sources1
Modified residuei52PhosphotyrosineCombined sources1
Modified residuei60N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei60N6-glutaryllysine; alternateBy similarity1
Cross-linki60Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei78N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei78N6-butyryllysine; alternateBy similarity1
Modified residuei78N6-glutaryllysine; alternateBy similarity1
Modified residuei78N6-propionyllysine; alternateBy similarity1
Modified residuei78N6-succinyllysine; alternate1 Publication1
Modified residuei80N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei80N6-butyryllysine; alternateBy similarity1
Modified residuei80N6-glutaryllysine; alternateBy similarity1
Modified residuei80N6-propionyllysine; alternateBy similarity1
Modified residuei80N6-succinyllysine; alternate1 Publication1
Cross-linki80Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei81PhosphothreonineCombined sources1
Modified residuei89PhosphotyrosineCombined sources1
Modified residuei92N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei92N6-acetyllysine; alternateBy similarity1
Modified residuei92N6-butyryllysine; alternateBy similarity1
Modified residuei92N6-glutaryllysine; alternateBy similarity1
Modified residuei92N6-propionyllysine; alternateBy similarity1
Modified residuei92N6-succinyllysine; alternateCombined sources1 Publication1
Cross-linki92Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki92Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.By similarity
Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.2 Publications
Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).By similarity
Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3) (PubMed:24049080). Monomethylation is performed by SET8 (By similarity). Dimethylation and trimethylation are performed by KMT5B and KMT5C and induce gene silencing (PubMed:24049080).By similarity1 Publication
Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).By similarity
Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).By similarity
Sumoylated, which is associated with transcriptional repression.By similarity
Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.1 Publication
Hydroxybutyrylation of histones is induced by starvation.1 Publication
Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.1 Publication
Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.By similarity

Keywords - PTMi

Acetylation, Citrullination, Hydroxylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
non-CPTAC-3425

Encyclopedia of Proteome Dynamics

More...
EPDi
P62806

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P62806

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P62806

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P62806

PRoteomics IDEntifications database

More...
PRIDEi
P62806

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P62806

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P62806

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P62806

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P62806

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000060093 Expressed in 42 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P62806 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P62806 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
213404, 2 interactors
220610, 5 interactors
235074, 2 interactors
235075, 3 interactors
235076, 1 interactor
235077, 1 interactor
235078, 1 interactor
235079, 2 interactors
235080, 1 interactor
235942, 13 interactors
236472, 6 interactors
236473, 2 interactors
784565, 1 interactor

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P62806

Database of interacting proteins

More...
DIPi
DIP-45837N

Protein interaction database and analysis system

More...
IntActi
P62806, 17 interactors

Molecular INTeraction database

More...
MINTi
P62806

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000136357

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1103
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P62806

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P62806

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the histone H4 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3467 Eukaryota
COG2036 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00970000193323
ENSGT00970000193418

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P62806

KEGG Orthology (KO)

More...
KOi
K11254

Identification of Orthologs from Complete Genome Data

More...
OMAi
QKEHING

Database of Orthologous Groups

More...
OrthoDBi
1594208at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P62806

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00076 H4, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.20.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035425 CENP-T/H4_C
IPR009072 Histone-fold
IPR001951 Histone_H4
IPR019809 Histone_H4_CS
IPR004823 TAF_TATA-bd

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15511 CENP-T_C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00623 HISTONEH4

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00417 H4, 1 hit
SM00803 TAF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47113 SSF47113, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00047 HISTONE_H4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P62806-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGRGKGGKG LGKGGAKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISGL
60 70 80 90 100
IYEETRGVLK VFLENVIRDA VTYTEHAKRK TVTAMDVVYA LKRQGRTLYG

FGG
Length:103
Mass (Da):11,367
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA9E5DFD3F8B97598
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti34A → V in BAB26692 (PubMed:16141072).Curated1
Sequence conflicti80K → E in BAB27698 (PubMed:16141072).Curated1
Sequence conflicti90A → R in CAA31622 (PubMed:2915930).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
V00753 Genomic DNA Translation: CAA24130.1
X13235 Genomic DNA Translation: CAA31621.1
X13236 Genomic DNA Translation: CAA31622.1
U62672 Genomic DNA Translation: AAB04766.1
Y12290 Genomic DNA Translation: CAA72967.1
AY158956 Genomic DNA Translation: AAO06266.1
AY158957 Genomic DNA Translation: AAO06267.1
AY158958 Genomic DNA Translation: AAO06268.1
AY158959 Genomic DNA Translation: AAO06269.1
AY158960 Genomic DNA Translation: AAO06270.1
AY158961 Genomic DNA Translation: AAO06271.1
AY158962 Genomic DNA Translation: AAO06272.1
AY158963 Genomic DNA Translation: AAO06273.1
AY158964 Genomic DNA Translation: AAO06274.1
AY158965 Genomic DNA Translation: AAO06275.1
AY158966 Genomic DNA Translation: AAO06276.1
AY158967 Genomic DNA Translation: AAO06277.1
AK007642 mRNA Translation: BAB25157.1
AK010085 mRNA Translation: BAB26692.1
AK011560 mRNA Translation: BAB27698.1
AK139521 mRNA Translation: BAE24047.1
AL589651 Genomic DNA No translation available.
AL590388 Genomic DNA No translation available.
AL590614 Genomic DNA No translation available.
BC028550 mRNA Translation: AAH28550.3
BC052219 mRNA No translation available.
BC057955 mRNA Translation: AAH57955.1
BC058529 mRNA Translation: AAH58529.2
BC087952 mRNA Translation: AAH87952.1
BC092144 mRNA Translation: AAH92144.1
BC115446 mRNA Translation: AAI15447.1
BC115447 mRNA Translation: AAI15448.1
BC115451 mRNA Translation: AAI15452.1
BC115448 mRNA Translation: AAI15449.1
BC115449 mRNA Translation: AAI15450.1
BC115450 mRNA Translation: AAI15451.1
BC117010 mRNA Translation: AAI17011.1
BC117012 mRNA Translation: AAI17013.1
BC111813 mRNA Translation: AAI11814.1
BC119241 mRNA Translation: AAI19242.1
BC119243 mRNA Translation: AAI19244.1
BC119611 mRNA Translation: AAI19612.1
BC119612 mRNA Translation: AAI19613.1
BC125598 mRNA Translation: AAI25599.1
BC125600 mRNA Translation: AAI25601.1
BC132186 mRNA Translation: AAI32187.1
BC132212 mRNA Translation: AAI32213.1
BC139809 mRNA Translation: AAI39810.1
BC152397 mRNA Translation: AAI52398.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS26291.1
CCDS26292.1
CCDS26300.1
CCDS26306.1
CCDS26340.1
CCDS26345.1
CCDS26353.1
CCDS26359.1
CCDS26366.1
CCDS26367.1
CCDS39684.1
CCDS51002.1
CCDS56872.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S03426
S03427

NCBI Reference Sequences

More...
RefSeqi
NP_001182350.1, NM_001195421.1
NP_291074.1, NM_033596.3
NP_694813.1, NM_153173.4
NP_783583.1, NM_175652.3
NP_783585.1, NM_175654.2
NP_783586.1, NM_175655.2
NP_783587.1, NM_175656.3
NP_783588.1, NM_175657.2
NP_835499.1, NM_178192.2
NP_835500.1, NM_178193.2
NP_835515.1, NM_178208.2
NP_835582.1, NM_178210.2
NP_835583.1, NM_178211.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000087714; ENSMUSP00000085006; ENSMUSG00000067455
ENSMUST00000102964; ENSMUSP00000100029; ENSMUSG00000060093
ENSMUST00000102965; ENSMUSP00000100030; ENSMUSG00000069266
ENSMUST00000102967; ENSMUSP00000100032; ENSMUSG00000060678
ENSMUST00000102968; ENSMUSP00000100033; ENSMUSG00000061482
ENSMUST00000102971; ENSMUSP00000100036; ENSMUSG00000069274
ENSMUST00000102972; ENSMUSP00000100037; ENSMUSG00000060981
ENSMUST00000102977; ENSMUSP00000100042; ENSMUSG00000060639
ENSMUST00000102979; ENSMUSP00000100044; ENSMUSG00000069305
ENSMUST00000102983; ENSMUSP00000100048; ENSMUSG00000064288
ENSMUST00000104941; ENSMUSP00000100546; ENSMUSG00000069306
ENSMUST00000171473; ENSMUSP00000129930; ENSMUSG00000091405
ENSMUST00000179285; ENSMUSP00000136357; ENSMUSG00000096010

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100041230
319155
319156
319157
319158
319159
319160
319161
320332
326619
326620
69386
97122

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:100041230
mmu:319155
mmu:319156
mmu:319157
mmu:319158
mmu:319159
mmu:319160
mmu:319161
mmu:320332
mmu:326619
mmu:326620
mmu:69386
mmu:97122

UCSC genome browser

More...
UCSCi
uc007pre.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00753 Genomic DNA Translation: CAA24130.1
X13235 Genomic DNA Translation: CAA31621.1
X13236 Genomic DNA Translation: CAA31622.1
U62672 Genomic DNA Translation: AAB04766.1
Y12290 Genomic DNA Translation: CAA72967.1
AY158956 Genomic DNA Translation: AAO06266.1
AY158957 Genomic DNA Translation: AAO06267.1
AY158958 Genomic DNA Translation: AAO06268.1
AY158959 Genomic DNA Translation: AAO06269.1
AY158960 Genomic DNA Translation: AAO06270.1
AY158961 Genomic DNA Translation: AAO06271.1
AY158962 Genomic DNA Translation: AAO06272.1
AY158963 Genomic DNA Translation: AAO06273.1
AY158964 Genomic DNA Translation: AAO06274.1
AY158965 Genomic DNA Translation: AAO06275.1
AY158966 Genomic DNA Translation: AAO06276.1
AY158967 Genomic DNA Translation: AAO06277.1
AK007642 mRNA Translation: BAB25157.1
AK010085 mRNA Translation: BAB26692.1
AK011560 mRNA Translation: BAB27698.1
AK139521 mRNA Translation: BAE24047.1
AL589651 Genomic DNA No translation available.
AL590388 Genomic DNA No translation available.
AL590614 Genomic DNA No translation available.
BC028550 mRNA Translation: AAH28550.3
BC052219 mRNA No translation available.
BC057955 mRNA Translation: AAH57955.1
BC058529 mRNA Translation: AAH58529.2
BC087952 mRNA Translation: AAH87952.1
BC092144 mRNA Translation: AAH92144.1
BC115446 mRNA Translation: AAI15447.1
BC115447 mRNA Translation: AAI15448.1
BC115451 mRNA Translation: AAI15452.1
BC115448 mRNA Translation: AAI15449.1
BC115449 mRNA Translation: AAI15450.1
BC115450 mRNA Translation: AAI15451.1
BC117010 mRNA Translation: AAI17011.1
BC117012 mRNA Translation: AAI17013.1
BC111813 mRNA Translation: AAI11814.1
BC119241 mRNA Translation: AAI19242.1
BC119243 mRNA Translation: AAI19244.1
BC119611 mRNA Translation: AAI19612.1
BC119612 mRNA Translation: AAI19613.1
BC125598 mRNA Translation: AAI25599.1
BC125600 mRNA Translation: AAI25601.1
BC132186 mRNA Translation: AAI32187.1
BC132212 mRNA Translation: AAI32213.1
BC139809 mRNA Translation: AAI39810.1
BC152397 mRNA Translation: AAI52398.1
CCDSiCCDS26291.1
CCDS26292.1
CCDS26300.1
CCDS26306.1
CCDS26340.1
CCDS26345.1
CCDS26353.1
CCDS26359.1
CCDS26366.1
CCDS26367.1
CCDS39684.1
CCDS51002.1
CCDS56872.1
PIRiS03426
S03427
RefSeqiNP_001182350.1, NM_001195421.1
NP_291074.1, NM_033596.3
NP_694813.1, NM_153173.4
NP_783583.1, NM_175652.3
NP_783585.1, NM_175654.2
NP_783586.1, NM_175655.2
NP_783587.1, NM_175656.3
NP_783588.1, NM_175657.2
NP_835499.1, NM_178192.2
NP_835500.1, NM_178193.2
NP_835515.1, NM_178208.2
NP_835582.1, NM_178210.2
NP_835583.1, NM_178211.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F66X-ray2.60B/F1-103[»]
1U35X-ray3.00B/F1-103[»]
2WP2X-ray2.37P/Q2-21[»]
4AU7X-ray2.07C18-25[»]
4DOWX-ray1.95C/D15-26[»]
5B1LX-ray2.35B/F1-103[»]
5B1MX-ray2.34B/F1-103[»]
5XM0X-ray2.87B/F1-103[»]
5XM1X-ray3.45B/F1-103[»]
SMRiP62806
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi213404, 2 interactors
220610, 5 interactors
235074, 2 interactors
235075, 3 interactors
235076, 1 interactor
235077, 1 interactor
235078, 1 interactor
235079, 2 interactors
235080, 1 interactor
235942, 13 interactors
236472, 6 interactors
236473, 2 interactors
784565, 1 interactor
CORUMiP62806
DIPiDIP-45837N
IntActiP62806, 17 interactors
MINTiP62806
STRINGi10090.ENSMUSP00000136357

PTM databases

iPTMnetiP62806
PhosphoSitePlusiP62806
SwissPalmiP62806

Proteomic databases

CPTACinon-CPTAC-3425
EPDiP62806
jPOSTiP62806
MaxQBiP62806
PaxDbiP62806
PRIDEiP62806
TopDownProteomicsiP62806

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
319156
319157
319159
320332
326620

Genome annotation databases

EnsembliENSMUST00000087714; ENSMUSP00000085006; ENSMUSG00000067455
ENSMUST00000102964; ENSMUSP00000100029; ENSMUSG00000060093
ENSMUST00000102965; ENSMUSP00000100030; ENSMUSG00000069266
ENSMUST00000102967; ENSMUSP00000100032; ENSMUSG00000060678
ENSMUST00000102968; ENSMUSP00000100033; ENSMUSG00000061482
ENSMUST00000102971; ENSMUSP00000100036; ENSMUSG00000069274
ENSMUST00000102972; ENSMUSP00000100037; ENSMUSG00000060981
ENSMUST00000102977; ENSMUSP00000100042; ENSMUSG00000060639
ENSMUST00000102979; ENSMUSP00000100044; ENSMUSG00000069305
ENSMUST00000102983; ENSMUSP00000100048; ENSMUSG00000064288
ENSMUST00000104941; ENSMUSP00000100546; ENSMUSG00000069306
ENSMUST00000171473; ENSMUSP00000129930; ENSMUSG00000091405
ENSMUST00000179285; ENSMUSP00000136357; ENSMUSG00000096010
GeneIDi100041230
319155
319156
319157
319158
319159
319160
319161
320332
326619
326620
69386
97122
KEGGimmu:100041230
mmu:319155
mmu:319156
mmu:319157
mmu:319158
mmu:319159
mmu:319160
mmu:319161
mmu:320332
mmu:326619
mmu:326620
mmu:69386
mmu:97122
UCSCiuc007pre.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
100041230
319161
320332
8294
8359
8360
8361
8362
8363
8364
8365
8366
8370
MGIiMGI:2448419 H4c1
MGI:2448436 H4c11
MGI:2448439 H4c12
MGI:2140113 H4c14
MGI:2448420 H4c2
MGI:2448421 H4c3
MGI:2448423 H4c4
MGI:2448425 H4c6
MGI:2448427 H4c8
MGI:2448432 H4c9
MGI:2448443 H4f16
MGI:2448441 Hist1h4m

Phylogenomic databases

eggNOGiKOG3467 Eukaryota
COG2036 LUCA
GeneTreeiENSGT00970000193323
ENSGT00970000193418
InParanoidiP62806
KOiK11254
OMAiQKEHING
OrthoDBi1594208at2759
PhylomeDBiP62806

Enzyme and pathway databases

ReactomeiR-MMU-110330 Recognition and association of DNA glycosylase with site containing an affected purine
R-MMU-110331 Cleavage of the damaged purine
R-MMU-171306 Packaging Of Telomere Ends
R-MMU-201722 Formation of the beta-catenin:TCF transactivating complex
R-MMU-212300 PRC2 methylates histones and DNA
R-MMU-2299718 Condensation of Prophase Chromosomes
R-MMU-2559580 Oxidative Stress Induced Senescence
R-MMU-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-MMU-2559586 DNA Damage/Telomere Stress Induced Senescence
R-MMU-3214841 PKMTs methylate histone lysines
R-MMU-3214842 HDMs demethylate histones
R-MMU-3214847 HATs acetylate histones
R-MMU-3214858 RMTs methylate histone arginines
R-MMU-427359 SIRT1 negatively regulates rRNA expression
R-MMU-427413 NoRC negatively regulates rRNA expression
R-MMU-4551638 SUMOylation of chromatin organization proteins
R-MMU-5250924 B-WICH complex positively regulates rRNA expression
R-MMU-5578749 Transcriptional regulation by small RNAs
R-MMU-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-MMU-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-MMU-5693571 Nonhomologous End-Joining (NHEJ)
R-MMU-5693607 Processing of DNA double-strand break ends
R-MMU-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-MMU-69473 G2/M DNA damage checkpoint
R-MMU-73728 RNA Polymerase I Promoter Opening
R-MMU-73772 RNA Polymerase I Promoter Escape
R-MMU-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-MMU-9018519 Estrogen-dependent gene expression

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Hist1h4b mouse
Hist1h4d mouse
Hist1h4h mouse
Hist1h4i mouse
EvolutionaryTraceiP62806

Protein Ontology

More...
PROi
PR:P62806

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000060093 Expressed in 42 organ(s), highest expression level in testis
ExpressionAtlasiP62806 baseline and differential
GenevisibleiP62806 MM

Family and domain databases

CDDicd00076 H4, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR035425 CENP-T/H4_C
IPR009072 Histone-fold
IPR001951 Histone_H4
IPR019809 Histone_H4_CS
IPR004823 TAF_TATA-bd
PfamiView protein in Pfam
PF15511 CENP-T_C, 1 hit
PRINTSiPR00623 HISTONEH4
SMARTiView protein in SMART
SM00417 H4, 1 hit
SM00803 TAF, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00047 HISTONE_H4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH4_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P62806
Secondary accession number(s): A0AUM5
, A4FUP8, A4QMY0, P02304, P02305, Q0VDL9, Q2M2Q5, Q5T006, Q6PDS7, Q811M0, Q9D0C9, Q9D6Q8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 13, 2019
This is version 172 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again