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Entry version 190 (31 Jul 2019)
Sequence version 3 (28 Mar 2018)
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Protein

Histone-lysine N-methyltransferase MECOM

Gene

MECOM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Isoform 1: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis.6 Publications
Isoform 7: Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri209 – 236C2H2-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri263 – 285C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri291 – 313C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri319 – 342C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri348 – 370C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri376 – 398C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri405 – 427C2H2-type 7; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri912 – 934C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri940 – 963C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri969 – 991C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Methyltransferase, Transferase
Biological processApoptosis, Differentiation, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3214841 PKMTs methylate histone lysines
R-HSA-8943724 Regulation of PTEN gene transcription

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q03112

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q03112

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferase MECOMCurated (EC:2.1.1.43By similarity)
Alternative name(s):
Ecotropic virus integration site 1 protein homolog
Short name:
EVI-1
MDS1 and EVI1 complex locus proteinCurated
Myelodysplasia syndrome 1 protein
Myelodysplasia syndrome-associated protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MECOMImported
Synonyms:EVI11 Publication, MDS11 Publication, PRDM31 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3498 MECOM

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
165215 gene
600049 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q03112

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving EVI1 is a cause of chronic myelogenous leukemia (CML). Translocation t(3;21)(q26;q22) with RUNX1/AML1.1 Publication
Radioulnar synostosis with amegakaryocytic thrombocytopenia 2 (RUSAT2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant disease characterized by proximal fusion of the radius and ulna resulting in extremely limited pronation and supination of the forearm, and congenital thrombocytopenia that progresses to pancytopenia.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_076308929R → W in RUSAT2; alters transcriptional regulation. 1 PublicationCorresponds to variant dbSNP:rs864309724Ensembl.1
Natural variantiVAR_076309930H → R in RUSAT2; alters transcriptional regulation. 1 PublicationCorresponds to variant dbSNP:rs864309723Ensembl.1
Natural variantiVAR_076310935T → A in RUSAT2; alters transcriptional regulation. 1 PublicationCorresponds to variant dbSNP:rs864309722Ensembl.1
A chromosomal aberration involving MDS1 is found in a form of acute myeloid leukemia (AML). Translocation t(3;21) with AML1.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi743 – 744DL → AS: Partial loss of interaction with CTBP1. Loss of interaction with CTBP1; when associated with 586-A-S-775. 1 Publication2
Mutagenesisi774 – 775DL → AS: Partial loss of interaction with CTBP1. Loss of interaction with CTBP1; when associated with 555-A-S-744. 1 Publication2

Keywords - Diseasei

Disease mutation, Proto-oncogene

Organism-specific databases

DisGeNET

More...
DisGeNETi
2122

MalaCards human disease database

More...
MalaCardsi
MECOM
MIMi616738 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000085276

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
402020 Acute myeloid leukemia with inv(3)(q21q26.2) or t(3;3)(q21;q26.2)
52688 Myelodysplastic syndrome
71289 Radio-ulnar synostosis-amegakaryocytic thrombocytopenia syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27912
PA30722

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
MECOM

Domain mapping of disease mutations (DMDM)

More...
DMDMi
145559472

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000472731 – 1230Histone-lysine N-methyltransferase MECOMAdd BLAST1230

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki99Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki190Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki249Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki292Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki367Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki374Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki430Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki523Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki543Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki547Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki555Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki622Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei624PhosphoserineCombined sources1
Cross-linki635Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki663Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki685Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki721Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei726PhosphoserineCombined sources1
Cross-linki731Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki732Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki735Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei740PhosphoserineBy similarity1
Cross-linki749Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki752Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki760Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki787Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki800Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki801Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki835Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki844Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki846Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki877Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1018Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1037PhosphoserineCombined sources1
Modified residuei1039PhosphoserineCombined sources1
Cross-linki1053Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1056Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1120Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1127Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1132Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1149Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1152Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1176Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1184Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Isoform 6 (identifier: Q03112-6)
Cross-linki138Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Isoform 4 (identifier: Q03112-4)
Cross-linki202Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki723Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Isoform 1 (identifier: Q03112-1)
Cross-linki658Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Isoform 2 (identifier: Q03112-3)
Cross-linki846Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources1 Publication
Isoform 8 (identifier: Q03112-8)
Cross-linki846Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated.By similarity
May be acetylated by CREBBP and KAT2B.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q03112

MaxQB - The MaxQuant DataBase

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MaxQBi
Q03112

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q03112

PeptideAtlas

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PeptideAtlasi
Q03112

PRoteomics IDEntifications database

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PRIDEi
Q03112

ProteomicsDB human proteome resource

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ProteomicsDBi
17508
58186 [Q03112-1]
58187 [Q03112-3]
58188 [Q03112-4]
58189 [Q03112-5]
58190 [Q03112-6]
59462

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q03112

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q03112

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000085276 Expressed in 221 organ(s), highest expression level in endometrium

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q03112 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q03112 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA046537

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Isoform 1: Homooligomer.

Interacts with SUV39H1 (via SET domain); enhances MECOM transcriptional repression activity (By similarity).

Interacts with CTBP1.

Interacts with SMAD3 (via MH2 domain); the interaction is direct.

Interacts with SMAD4; through interaction with SMAD3.

Interacts with CREBBP, KAT2B and histone deacetylases.

Interacts with MAPK8 and MAPK9; inhibits JNK signaling (PubMed:10856240, PubMed:11568182, PubMed:15897867, PubMed:9665135).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108423, 54 interactors

Database of interacting proteins

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DIPi
DIP-38639N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q03112

Protein interaction database and analysis system

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IntActi
Q03112, 15 interactors

Molecular INTeraction database

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MINTi
Q03112

STRING: functional protein association networks

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STRINGi
9606.ENSP00000264674

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q03112

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini78 – 190SETPROSITE-ProRule annotationAdd BLAST113

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni189 – 440Interaction with MAPK9, SMAD3 and probably SUV39H11 PublicationAdd BLAST252

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi609 – 622Nuclear localization signalSequence analysisAdd BLAST14
Motifi741 – 745CTBP-binding motif 1By similarity5
Motifi772 – 776CTBP-binding motif 2By similarity5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1065 – 1116Asp/Glu-rich (acidic)Add BLAST52

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Both zinc finger regions are required for the transcriptional activation of PBX1.

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri209 – 236C2H2-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri263 – 285C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri291 – 313C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri319 – 342C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri348 – 370C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri376 – 398C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri405 – 427C2H2-type 7; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri912 – 934C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri940 – 963C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri969 – 991C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157208

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q03112

KEGG Orthology (KO)

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KOi
K04462

Identification of Orthologs from Complete Genome Data

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OMAi
SMVNMNH

Database of Orthologous Groups

More...
OrthoDBi
406002at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q03112

TreeFam database of animal gene trees

More...
TreeFami
TF315309

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001214 SET_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096 zf-C2H2, 8 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00317 SET, 1 hit
SM00355 ZnF_C2H2, 10 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50280 SET, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 8 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 7 (identifier: Q03112-7) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRSKGRARKL ATNNECVYGN YPEIPLEEMP DADGVASTPS LNIQEPCSPA
60 70 80 90 100
TSSEAFTPKE GSPYKAPIYI PDDIPIPAEF ELRESNMPGA GLGIWTKRKI
110 120 130 140 150
EVGEKFGPYV GEQRSNLKDP SYGWEILDEF YNVKFCIDAS QPDVGSWLKY
160 170 180 190 200
IRFAGCYDQH NLVACQINDQ IFYRVVADIA PGEELLLFMK SEDYPHETMA
210 220 230 240 250
PDIHEERQYR CEDCDQLFES KAELADHQKF PCSTPHSAFS MVEEDFQQKL
260 270 280 290 300
ESENDLQEIH TIQECKECDQ VFPDLQSLEK HMLSHTEERE YKCDQCPKAF
310 320 330 340 350
NWKSNLIRHQ MSHDSGKHYE CENCAKVFTD PSNLQRHIRS QHVGARAHAC
360 370 380 390 400
PECGKTFATS SGLKQHKHIH SSVKPFICEV CHKSYTQFSN LCRHKRMHAD
410 420 430 440 450
CRTQIKCKDC GQMFSTTSSL NKHRRFCEGK NHFAAGGFFG QGISLPGTPA
460 470 480 490 500
MDKTSMVNMS HANPGLADYF GANRHPAGLT FPTAPGFSFS FPGLFPSGLY
510 520 530 540 550
HRPPLIPASS PVKGLSSTEQ TNKSQSPLMT HPQILPATQD ILKALSKHPS
560 570 580 590 600
VGDNKPVELQ PERSSEERPF EKISDQSESS DLDDVSTPSG SDLETTSGSD
610 620 630 640 650
LESDIESDKE KFKENGKMFK DKVSPLQNLA SINNKKEYSN HSIFSPSLEE
660 670 680 690 700
QTAVSGAVND SIKAIASIAE KYFGSTGLVG LQDKKVGALP YPSMFPLPFF
710 720 730 740 750
PAFSQSMYPF PDRDLRSLPL KMEPQSPGEV KKLQKGSSES PFDLTTKRKD
760 770 780 790 800
EKPLTPVPSK PPVTPATSQD QPLDLSMGSR SRASGTKLTE PRKNHVFGGK
810 820 830 840 850
KGSNVESRPA SDGSLQHARP TPFFMDPIYR VEKRKLTDPL EALKEKYLRP
860 870 880 890 900
SPGFLFHPQM SAIENMAEKL ESFSALKPEA SELLQSVPSM FNFRAPPNAL
910 920 930 940 950
PENLLRKGKE RYTCRYCGKI FPRSANLTRH LRTHTGEQPY RCKYCDRSFS
960 970 980 990 1000
ISSNLQRHVR NIHNKEKPFK CHLCDRCFGQ QTNLDRHLKK HENGNMSGTA
1010 1020 1030 1040 1050
TSSPHSELES TGAILDDKED AYFTEIRNFI GNSNHGSQSP RNVEERMNGS
1060 1070 1080 1090 1100
HFKDEKALVT SQNSDLLDDE EVEDEVLLDE EDEDNDITGK TGKEPVTSNL
1110 1120 1130 1140 1150
HEGNPEDDYE ETSALEMSCK TSPVRYKEEE YKSGLSALDH IRHFTDSLKM
1160 1170 1180 1190 1200
RKMEDNQYSE AELSSFSTSH VPEELKQPLH RKSKSQAYAM MLSLSDKESL
1210 1220 1230
HSTSHSSSNV WHSMARAAAE SSAIQSISHV
Length:1,230
Mass (Da):138,136
Last modified:March 28, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i49E9B7CBCD422042
GO
Isoform 1 (identifier: Q03112-1) [UniParc]FASTAAdd to basket
Also known as: Long, Evi-1a

The sequence of this isoform differs from the canonical sequence as follows:
     1-188: Missing.
     859-859: Q → QFQLPDQRTW

Show »
Length:1,051
Mass (Da):118,276
Checksum:iBD132C53EA08D263
GO
Isoform 2 (identifier: Q03112-3) [UniParc]FASTAAdd to basket
Also known as: Evi-1c, Mds1/Evi1

The sequence of this isoform differs from the canonical sequence as follows:
     859-859: Q → QFQLPDQRTW

Note: Produced by alternative promoter usage. Unable to form homooligomers, to interact with CTBP1 and SMAD3 and to repress TGF-beta signaling.Combined sources1 Publication
Show »
Length:1,239
Mass (Da):139,308
Checksum:iE8A5EAD310102D53
GO
Isoform 4 (identifier: Q03112-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-125: MRSKGRARKL...NLKDPSYGWE → M
     326-326: K → KQ
     859-859: Q → QFQLPDQRTW

Show »
Length:1,116
Mass (Da):125,807
Checksum:i772D3F793270B394
GO
Isoform 5 (identifier: Q03112-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-188: Missing.

Show »
Length:1,042
Mass (Da):117,104
Checksum:i97476C1D04DB2007
GO
Isoform 6 (identifier: Q03112-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-188: Missing.
     326-326: K → KQ

Show »
Length:1,043
Mass (Da):117,232
Checksum:iB6A0605E499FF208
GO
Isoform 8 (identifier: Q03112-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     859-859: Q → QFQLPDQRTW
     939-945: PYRCKYC → LKNKDLQ
     946-1230: Missing.

Show »
Length:954
Mass (Da):107,019
Checksum:iE100813B49C6BD79
GO
Isoform 9 (identifier: Q03112-9) [UniParc]FASTAAdd to basket
Also known as: MDS1

The sequence of this isoform differs from the canonical sequence as follows:
     126-169: ILDEFYNVKF...HNLVACQIND → VHLPRSRRVS...MPGLQCAFLS
     170-1230: Missing.

Note: Produced by alternative promoter usage.
Show »
Length:169
Mass (Da):18,696
Checksum:i3EE36C8ACB62EFFE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EUL6E7EUL6_HUMAN
Histone-lysine N-methyltransferase ...
MECOM
1,003Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C3SFZ7A0A0C3SFZ7_HUMAN
Histone-lysine N-methyltransferase ...
MECOM
1,052Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H9KVD4H9KVD4_HUMAN
Histone-lysine N-methyltransferase ...
MECOM
321Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JU02C9JU02_HUMAN
Histone-lysine N-methyltransferase ...
MECOM
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ERX0E7ERX0_HUMAN
Histone-lysine N-methyltransferase ...
MECOM
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EPY2E7EPY2_HUMAN
Histone-lysine N-methyltransferase ...
MECOM
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EU48E7EU48_HUMAN
Histone-lysine N-methyltransferase ...
MECOM
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PGE9E9PGE9_HUMAN
Histone-lysine N-methyltransferase ...
MECOM
28Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GXI8A0A1B0GXI8_HUMAN
Histone-lysine N-methyltransferase ...
MECOM
21Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB29907 differs from that shown. Chimeric cDNA that is the result of a chromosomal aberration involving EVI1 and RUNX1.Curated
The sequence AAB29907 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAI30521 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti126 – 127IL → VR in AAB05840 (PubMed:8643684).Curated2
Sequence conflicti208Q → R in CAE45952 (PubMed:17974005).Curated1
Sequence conflicti363L → P in CAE45952 (PubMed:17974005).Curated1
Sequence conflicti489F → S in BAF85554 (PubMed:14702039).Curated1
Sequence conflicti491F → V in CAA38735 (PubMed:2115646).Curated1
Sequence conflicti631S → P in CAI46086 (PubMed:17974005).Curated1
Sequence conflicti731K → R in CAE45952 (PubMed:17974005).Curated1
Sequence conflicti909K → R in BAF85554 (PubMed:14702039).Curated1
Sequence conflicti920I → V in CAI46086 (PubMed:17974005).Curated1
Sequence conflicti975D → Y in CAA38735 (PubMed:2115646).Curated1
Sequence conflicti1054D → E in CAA38735 (PubMed:2115646).Curated1
Sequence conflicti1060T → P in CAA38735 (PubMed:2115646).Curated1
Sequence conflicti1085N → Y in CAA38735 (PubMed:2115646).Curated1
Sequence conflicti1171V → A in BAF85554 (PubMed:14702039).Curated1
Sequence conflicti1187 – 1191AYAMM → VQIFP in AAB37456 (PubMed:8700545).Curated5
Sequence conflicti1192L → P in CAE45952 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051183120P → S. Corresponds to variant dbSNP:rs7622799Ensembl.1
Natural variantiVAR_061928295Q → R. Corresponds to variant dbSNP:rs34896995Ensembl.1
Natural variantiVAR_076308929R → W in RUSAT2; alters transcriptional regulation. 1 PublicationCorresponds to variant dbSNP:rs864309724Ensembl.1
Natural variantiVAR_076309930H → R in RUSAT2; alters transcriptional regulation. 1 PublicationCorresponds to variant dbSNP:rs864309723Ensembl.1
Natural variantiVAR_076310935T → A in RUSAT2; alters transcriptional regulation. 1 PublicationCorresponds to variant dbSNP:rs864309722Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0594791 – 188Missing in isoform 1, isoform 5 and isoform 6. Add BLAST188
Alternative sequenceiVSP_0594801 – 125MRSKG…SYGWE → M in isoform 4. Add BLAST125
Alternative sequenceiVSP_059481126 – 169ILDEF…CQIND → VHLPRSRRVSVHSWLYLGKR SSDVGIAFSQADVYMPGLQC AFLS in isoform 9. Add BLAST44
Alternative sequenceiVSP_059482170 – 1230Missing in isoform 9. Add BLAST1061
Alternative sequenceiVSP_059483326K → KQ in isoform 4 and isoform 6. 1
Alternative sequenceiVSP_059484859Q → QFQLPDQRTW in isoform 1, isoform 4, isoform 8 and isoform 2. 1
Alternative sequenceiVSP_059485939 – 945PYRCKYC → LKNKDLQ in isoform 8. 7
Alternative sequenceiVSP_059486946 – 1230Missing in isoform 8. Add BLAST285

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X54989 mRNA Translation: CAA38735.1
U43292 mRNA Translation: AAB05839.1
U43293 mRNA Translation: AAB05840.1
AK292865 mRNA Translation: BAF85554.1
AK304098 mRNA Translation: BAH14103.1
CR541866 mRNA Translation: CAG46664.1
CR541886 mRNA Translation: CAG46684.1
BX640908 mRNA Translation: CAE45952.1
BX647613 mRNA Translation: CAI46086.1
AC007849 Genomic DNA No translation available.
AC024099 Genomic DNA No translation available.
AC069220 Genomic DNA No translation available.
AC074033 Genomic DNA No translation available.
AC078985 Genomic DNA No translation available.
KF457717 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78549.1
CH471052 Genomic DNA Translation: EAW78553.1
CH471052 Genomic DNA Translation: EAW78556.1
CH471052 Genomic DNA Translation: EAW78557.1
BC031019 mRNA Translation: AAH31019.1
BC069498 mRNA Translation: AAH69498.1
BC130520 mRNA Translation: AAI30521.1 Different initiation.
BC143951 mRNA Translation: AAI43952.1
BC143952 mRNA Translation: AAI43953.1
S69002 mRNA Translation: AAB29907.1 Sequence problems.
S82592 mRNA Translation: AAB37456.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3205.1 [Q03112-1]
CCDS54669.1 [Q03112-5]
CCDS54670.1 [Q03112-4]

Protein sequence database of the Protein Information Resource

More...
PIRi
A60191
S41705

NCBI Reference Sequences

More...
RefSeqi
NP_001098547.3, NM_001105077.3 [Q03112-4]
NP_001098548.2, NM_001105078.3 [Q03112-1]
NP_001157471.1, NM_001163999.1 [Q03112-6]
NP_001157472.1, NM_001164000.1 [Q03112-5]
NP_001192123.1, NM_001205194.1 [Q03112-1]
NP_004982.2, NM_004991.3 [Q03112-3]
NP_005232.2, NM_005241.3 [Q03112-1]
XP_005247272.1, XM_005247215.3
XP_005247276.1, XM_005247219.2
XP_005247277.1, XM_005247220.2
XP_005247278.1, XM_005247221.2
XP_005247280.1, XM_005247223.2
XP_016861363.1, XM_017005874.1 [Q03112-4]
XP_016861364.1, XM_017005875.1
XP_016861365.1, XM_017005876.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000264674; ENSP00000264674; ENSG00000085276 [Q03112-4]
ENST00000464456; ENSP00000419770; ENSG00000085276 [Q03112-5]
ENST00000468789; ENSP00000419995; ENSG00000085276 [Q03112-1]
ENST00000494292; ENSP00000417899; ENSG00000085276 [Q03112-7]
ENST00000628990; ENSP00000486104; ENSG00000085276 [Q03112-1]
ENST00000651503; ENSP00000498411; ENSG00000085276 [Q03112-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2122

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2122

UCSC genome browser

More...
UCSCi
uc003ffi.3 human [Q03112-7]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54989 mRNA Translation: CAA38735.1
U43292 mRNA Translation: AAB05839.1
U43293 mRNA Translation: AAB05840.1
AK292865 mRNA Translation: BAF85554.1
AK304098 mRNA Translation: BAH14103.1
CR541866 mRNA Translation: CAG46664.1
CR541886 mRNA Translation: CAG46684.1
BX640908 mRNA Translation: CAE45952.1
BX647613 mRNA Translation: CAI46086.1
AC007849 Genomic DNA No translation available.
AC024099 Genomic DNA No translation available.
AC069220 Genomic DNA No translation available.
AC074033 Genomic DNA No translation available.
AC078985 Genomic DNA No translation available.
KF457717 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78549.1
CH471052 Genomic DNA Translation: EAW78553.1
CH471052 Genomic DNA Translation: EAW78556.1
CH471052 Genomic DNA Translation: EAW78557.1
BC031019 mRNA Translation: AAH31019.1
BC069498 mRNA Translation: AAH69498.1
BC130520 mRNA Translation: AAI30521.1 Different initiation.
BC143951 mRNA Translation: AAI43952.1
BC143952 mRNA Translation: AAI43953.1
S69002 mRNA Translation: AAB29907.1 Sequence problems.
S82592 mRNA Translation: AAB37456.1
CCDSiCCDS3205.1 [Q03112-1]
CCDS54669.1 [Q03112-5]
CCDS54670.1 [Q03112-4]
PIRiA60191
S41705
RefSeqiNP_001098547.3, NM_001105077.3 [Q03112-4]
NP_001098548.2, NM_001105078.3 [Q03112-1]
NP_001157471.1, NM_001163999.1 [Q03112-6]
NP_001157472.1, NM_001164000.1 [Q03112-5]
NP_001192123.1, NM_001205194.1 [Q03112-1]
NP_004982.2, NM_004991.3 [Q03112-3]
NP_005232.2, NM_005241.3 [Q03112-1]
XP_005247272.1, XM_005247215.3
XP_005247276.1, XM_005247219.2
XP_005247277.1, XM_005247220.2
XP_005247278.1, XM_005247221.2
XP_005247280.1, XM_005247223.2
XP_016861363.1, XM_017005874.1 [Q03112-4]
XP_016861364.1, XM_017005875.1
XP_016861365.1, XM_017005876.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6BW3X-ray2.20B/D1-12[»]
SMRiQ03112
ModBaseiSearch...

Protein-protein interaction databases

BioGridi108423, 54 interactors
DIPiDIP-38639N
ELMiQ03112
IntActiQ03112, 15 interactors
MINTiQ03112
STRINGi9606.ENSP00000264674

PTM databases

iPTMnetiQ03112
PhosphoSitePlusiQ03112

Polymorphism and mutation databases

BioMutaiMECOM
DMDMi145559472

Proteomic databases

jPOSTiQ03112
MaxQBiQ03112
PaxDbiQ03112
PeptideAtlasiQ03112
PRIDEiQ03112
ProteomicsDBi17508
58186 [Q03112-1]
58187 [Q03112-3]
58188 [Q03112-4]
58189 [Q03112-5]
58190 [Q03112-6]
59462

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
2122
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264674; ENSP00000264674; ENSG00000085276 [Q03112-4]
ENST00000464456; ENSP00000419770; ENSG00000085276 [Q03112-5]
ENST00000468789; ENSP00000419995; ENSG00000085276 [Q03112-1]
ENST00000494292; ENSP00000417899; ENSG00000085276 [Q03112-7]
ENST00000628990; ENSP00000486104; ENSG00000085276 [Q03112-1]
ENST00000651503; ENSP00000498411; ENSG00000085276 [Q03112-3]
GeneIDi2122
KEGGihsa:2122
UCSCiuc003ffi.3 human [Q03112-7]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2122
DisGeNETi2122

GeneCards: human genes, protein and diseases

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GeneCardsi
MECOM
HGNCiHGNC:3498 MECOM
HPAiHPA046537
MalaCardsiMECOM
MIMi165215 gene
600049 gene
616738 phenotype
neXtProtiNX_Q03112
OpenTargetsiENSG00000085276
Orphaneti402020 Acute myeloid leukemia with inv(3)(q21q26.2) or t(3;3)(q21;q26.2)
52688 Myelodysplastic syndrome
71289 Radio-ulnar synostosis-amegakaryocytic thrombocytopenia syndrome
PharmGKBiPA27912
PA30722

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000157208
InParanoidiQ03112
KOiK04462
OMAiSMVNMNH
OrthoDBi406002at2759
PhylomeDBiQ03112
TreeFamiTF315309

Enzyme and pathway databases

ReactomeiR-HSA-3214841 PKMTs methylate histone lysines
R-HSA-8943724 Regulation of PTEN gene transcription
SignaLinkiQ03112
SIGNORiQ03112

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MECOM human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MECOM

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2122

Protein Ontology

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PROi
PR:Q03112

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000085276 Expressed in 221 organ(s), highest expression level in endometrium
ExpressionAtlasiQ03112 baseline and differential
GenevisibleiQ03112 HS

Family and domain databases

InterProiView protein in InterPro
IPR001214 SET_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 8 hits
SMARTiView protein in SMART
SM00317 SET, 1 hit
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50280 SET, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMECOM_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q03112
Secondary accession number(s): A1L4F3
, A8KA00, B7Z8W7, B7ZLQ3, B7ZLQ4, C9JAK0, D3DNP7, E7EQ57, Q13465, Q13466, Q16122, Q5HYI1, Q6FH90, Q6MZS6, Q8NEI5, Q99917
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: March 28, 2018
Last modified: July 31, 2019
This is version 190 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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