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Entry version 174 (13 Nov 2019)
Sequence version 2 (24 May 2005)
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Protein

Potassium voltage-gated channel subfamily C member 4

Gene

KCNC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1296072 Voltage gated Potassium channels

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q03721

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily C member 4
Alternative name(s):
KSHIIIC
Voltage-gated potassium channel subunit Kv3.4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KCNC4Imported
Synonyms:C1orf30Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6236 KCNC4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
176265 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q03721

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 226CytoplasmicSequence analysisAdd BLAST226
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei227 – 247Helical; Name=Segment S1Sequence analysisAdd BLAST21
Transmembranei278 – 298Helical; Name=Segment S2Sequence analysisAdd BLAST21
Topological domaini299 – 312CytoplasmicSequence analysisAdd BLAST14
Transmembranei313 – 333Helical; Name=Segment S3Sequence analysisAdd BLAST21
Transmembranei345 – 364Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST20
Topological domaini365 – 380CytoplasmicSequence analysisAdd BLAST16
Transmembranei381 – 401Helical; Name=Segment S5Sequence analysisAdd BLAST21
Transmembranei452 – 472Helical; Name=Segment S6Sequence analysisAdd BLAST21
Topological domaini473 – 635CytoplasmicSequence analysisAdd BLAST163

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi8S → A: Decreased inhibition of channel closure by PKC. Inhibition of channel closure is nearly abolished; when associated with A-9. 1 Publication1
Mutagenesisi8S → D: Decreased rate of channel inactivation. Loss of channel inactivation; when associated with D-9; D-15 and D-21. 1 Publication1
Mutagenesisi9S → A: Strong decrease of inhibition of channel closure by PKC. Inhibition of channel closure is nearly abolished; when associated with A-8. 1 Publication1
Mutagenesisi9S → D: Decreased rate of channel inactivation. Loss of channel inactivation; when associated with D-8; D-15 and D-21. 1 Publication1
Mutagenesisi15S → A: Decreased inhibition of channel closure by PKC. 2 Publications1
Mutagenesisi15S → D: Slightly decreased rate of channel inactivation. Loss of channel inactivation; when associated with D-8; D-9 and D-21. 2 Publications1
Mutagenesisi21S → A: Decreased inhibition of channel closure by PKC. 2 Publications1
Mutagenesisi21S → D: Slightly decreased rate of channel inactivation. Loss of channel inactivation; when associated with D-8; D-9 and D-15. 2 Publications1

Organism-specific databases

DisGeNET

More...
DisGeNETi
3749

Open Targets

More...
OpenTargetsi
ENSG00000116396

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30028

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q03721

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2362996

Drug and drug target database

More...
DrugBanki
DB04522 Dexfosfoserine

DrugCentral

More...
DrugCentrali
Q03721

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KCNC4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
66774206

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000540581 – 635Potassium voltage-gated channel subfamily C member 4Add BLAST635

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei8Phosphoserine1 Publication1
Modified residuei9Phosphoserine1 Publication1
Modified residuei15Phosphoserine1 Publication1
Modified residuei21Phosphoserine1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi256N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi265N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation of serine residues in the inactivation gate inhibits rapid channel closure.2 Publications

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q03721

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q03721

PeptideAtlas

More...
PeptideAtlasi
Q03721

PRoteomics IDEntifications database

More...
PRIDEi
Q03721

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
58220 [Q03721-1]
58221 [Q03721-2]
58222 [Q03721-3]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q03721-3 [Q03721-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q03721

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q03721

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000116396 Expressed in 145 organ(s), highest expression level in hypothalamus

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q03721 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q03721 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA014740

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer (Probable). Heterotetramer of potassium channel proteins (By similarity).

By similarityCurated

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
P568173EBI-11334865,EBI-2433139

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109951, 32 interactors

Protein interaction database and analysis system

More...
IntActi
Q03721, 29 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000358802

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1635
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q03721

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q03721

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 28Inactivation gateAdd BLAST28

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi436 – 441Selectivity filterBy similarity6

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3713 Eukaryota
COG1226 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158860

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231012

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q03721

KEGG Orthology (KO)

More...
KOi
K04890

Identification of Orthologs from Complete Genome Data

More...
OMAi
YAQPEVT

Database of Orthologous Groups

More...
OrthoDBi
818306at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q03721

TreeFam database of animal gene trees

More...
TreeFami
TF352511

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000210 BTB/POZ_dom
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003974 K_chnl_volt-dep_Kv3
IPR005405 K_chnl_volt-dep_Kv3.4
IPR021105 K_chnl_volt-dep_Kv3_ID
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11537 PTHR11537, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02214 BTB_2, 1 hit
PF00520 Ion_trans, 1 hit
PF11404 Potassium_chann, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01583 KV34CHANNEL
PR01491 KVCHANNEL
PR01498 SHAWCHANNEL

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00225 BTB, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54695 SSF54695, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q03721-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MISSVCVSSY RGRKSGNKPP SKTCLKEEMA KGEASEKIII NVGGTRHETY
60 70 80 90 100
RSTLRTLPGT RLAWLADPDG GGRPETDGGG VGSSGSSGGG GCEFFFDRHP
110 120 130 140 150
GVFAYVLNYY RTGKLHCPAD VCGPLFEEEL TFWGIDETDV EPCCWMTYRQ
160 170 180 190 200
HRDAEEALDI FESPDGGGSG AGPSDEAGDD ERELALQRLG PHEGGAGHGA
210 220 230 240 250
GSGGCRGWQP RMWALFEDPY SSRAARVVAF ASLFFILVSI TTFCLETHEA
260 270 280 290 300
FNIDRNVTEI LRVGNITSVH FRREVETEPI LTYIEGVCVL WFTLEFLVRI
310 320 330 340 350
VCCPDTLDFV KNLLNIIDFV AILPFYLEVG LSGLSSKAAR DVLGFLRVVR
360 370 380 390 400
FVRILRIFKL TRHFVGLRVL GHTLRASTNE FLLLIIFLAL GVLIFATMIY
410 420 430 440 450
YAERIGARPS DPRGNDHTDF KNIPIGFWWA VVTMTTLGYG DMYPKTWSGM
460 470 480 490 500
LVGALCALAG VLTIAMPVPV IVNNFGMYYS LAMAKQKLPK KRKKHVPRPA
510 520 530 540 550
QLESPMYCKS EETSPRDSTC SDTSPPAREE GMIERKRADS KQNGDANAVL
560 570 580 590 600
SDEEGAGLTQ PLASSPTPEE RRALRRSTTR DRNKKAAACF LLSTGDYACA
610 620 630
DGSVRKGTFV LRDLPLQHSP EAACPPTAGT LFLPH
Length:635
Mass (Da):69,767
Last modified:May 24, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8A36F0A16AD17722
GO
Isoform 2 (identifier: Q03721-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     539-582: DSKQNGDANA...ALRRSTTRDR → GEIRGWEGKS...GFPKHKDVPL
     583-635: Missing.

Note: Could be a cloning artifact.
Show »
Length:582
Mass (Da):64,547
Checksum:i427587A53154E5E0
GO
Isoform 3 (identifier: Q03721-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     607-635: GTFVLRDLPLQHSPEAACPPTAGTLFLPH → ETCQDALSSNYAQAEVLTLS

Note: Gene prediction based on EST data.
Show »
Length:626
Mass (Da):68,824
Checksum:i25385AD738077B52
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BZ66H7BZ66_HUMAN
Potassium voltage-gated channel sub...
KCNC4
624Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GVB7A0A1B0GVB7_HUMAN
Potassium voltage-gated channel sub...
KCNC4
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti86S → T in AAA57263 (PubMed:1381835).Curated1
Sequence conflicti351F → I in AAA57263 (PubMed:1381835).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034051318D → Y. Corresponds to variant dbSNP:rs35167146Ensembl.1
Natural variantiVAR_062185516R → Q. Corresponds to variant dbSNP:rs59123361Ensembl.1
Natural variantiVAR_027505520C → Y. Corresponds to variant dbSNP:rs12411176Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_020581539 – 582DSKQN…TTRDR → GEIRGWEGKSLFPQWPREFP NGPQTLGFGMCFVWGFPKHK DVPL in isoform 2. 2 PublicationsAdd BLAST44
Alternative sequenceiVSP_020582583 – 635Missing in isoform 2. 2 PublicationsAdd BLAST53
Alternative sequenceiVSP_040033607 – 635GTFVL…LFLPH → ETCQDALSSNYAQAEVLTLS in isoform 3. CuratedAdd BLAST29

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M64676 mRNA Translation: AAA57263.1
AL137790 Genomic DNA No translation available.
BC019010 mRNA No translation available.
BC101769 mRNA Translation: AAI01770.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS44193.1 [Q03721-3]
CCDS821.1 [Q03721-1]

NCBI Reference Sequences

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RefSeqi
NP_001034663.1, NM_001039574.2 [Q03721-3]
NP_004969.2, NM_004978.4 [Q03721-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000369787; ENSP00000358802; ENSG00000116396 [Q03721-1]
ENST00000438661; ENSP00000393655; ENSG00000116396 [Q03721-3]
ENST00000469655; ENSP00000436656; ENSG00000116396 [Q03721-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
3749

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3749

UCSC genome browser

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UCSCi
uc001dzg.4 human [Q03721-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64676 mRNA Translation: AAA57263.1
AL137790 Genomic DNA No translation available.
BC019010 mRNA No translation available.
BC101769 mRNA Translation: AAI01770.1
CCDSiCCDS44193.1 [Q03721-3]
CCDS821.1 [Q03721-1]
RefSeqiNP_001034663.1, NM_001039574.2 [Q03721-3]
NP_004969.2, NM_004978.4 [Q03721-1]

3D structure databases

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Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B4GNMR-A1-30[»]
1B4INMR-A1-30[»]
1ZTNNMR-A1-30[»]
SMRiQ03721
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi109951, 32 interactors
IntActiQ03721, 29 interactors
STRINGi9606.ENSP00000358802

Chemistry databases

ChEMBLiCHEMBL2362996
DrugBankiDB04522 Dexfosfoserine
DrugCentraliQ03721

PTM databases

iPTMnetiQ03721
PhosphoSitePlusiQ03721

Polymorphism and mutation databases

BioMutaiKCNC4
DMDMi66774206

Proteomic databases

MassIVEiQ03721
PaxDbiQ03721
PeptideAtlasiQ03721
PRIDEiQ03721
ProteomicsDBi58220 [Q03721-1]
58221 [Q03721-2]
58222 [Q03721-3]
TopDownProteomicsiQ03721-3 [Q03721-3]

Genome annotation databases

EnsembliENST00000369787; ENSP00000358802; ENSG00000116396 [Q03721-1]
ENST00000438661; ENSP00000393655; ENSG00000116396 [Q03721-3]
ENST00000469655; ENSP00000436656; ENSG00000116396 [Q03721-1]
GeneIDi3749
KEGGihsa:3749
UCSCiuc001dzg.4 human [Q03721-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3749
DisGeNETi3749

GeneCards: human genes, protein and diseases

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GeneCardsi
KCNC4
HGNCiHGNC:6236 KCNC4
HPAiHPA014740
MIMi176265 gene
neXtProtiNX_Q03721
OpenTargetsiENSG00000116396
PharmGKBiPA30028

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3713 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00940000158860
HOGENOMiHOG000231012
InParanoidiQ03721
KOiK04890
OMAiYAQPEVT
OrthoDBi818306at2759
PhylomeDBiQ03721
TreeFamiTF352511

Enzyme and pathway databases

ReactomeiR-HSA-1296072 Voltage gated Potassium channels
SIGNORiQ03721

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
KCNC4 human
EvolutionaryTraceiQ03721

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
KCNC4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3749
PharosiQ03721

Protein Ontology

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PROi
PR:Q03721

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000116396 Expressed in 145 organ(s), highest expression level in hypothalamus
ExpressionAtlasiQ03721 baseline and differential
GenevisibleiQ03721 HS

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003974 K_chnl_volt-dep_Kv3
IPR005405 K_chnl_volt-dep_Kv3.4
IPR021105 K_chnl_volt-dep_Kv3_ID
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR11537 PTHR11537, 1 hit
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
PF00520 Ion_trans, 1 hit
PF11404 Potassium_chann, 1 hit
PRINTSiPR01583 KV34CHANNEL
PR01491 KVCHANNEL
PR01498 SHAWCHANNEL
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCNC4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q03721
Secondary accession number(s): Q3MIM4, Q5TBI6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 24, 2005
Last modified: November 13, 2019
This is version 174 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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