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Entry version 193 (16 Oct 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Poly(rC)-binding protein 2

Gene

PCBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509).2 Publications
(Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943, PubMed:24371074). Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Ribonucleoprotein, RNA-binding
Biological processAntiviral defense, Immunity, Innate immunity, Viral RNA replication

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Poly(rC)-binding protein 2
Alternative name(s):
Alpha-CP2
Heterogeneous nuclear ribonucleoprotein E2
Short name:
hnRNP E2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PCBP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8648 PCBP2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601210 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q15366

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
5094

Open Targets

More...
OpenTargetsi
ENSG00000197111

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA32987

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q15366

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PCBP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
6707736

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000500901 – 365Poly(rC)-binding protein 2Add BLAST365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki115Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei173PhosphoserineCombined sources1
Cross-linki185Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei189PhosphoserineCombined sources1
Modified residuei272PhosphoserineCombined sources1
Cross-linki322Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei364PhosphoserineCombined sources1
Modified residuei365PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated. The non-phosphorylated form(s) exhibited the strongest poly(rC)-binding activity.
(Microbial infection) Proteolyticaly cleaved by picornavirus proteinase 3CD.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei253 – 254Cleavage, by viral proteinase 3CD1 Publication2

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q15366

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q15366

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q15366

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q15366

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q15366

PeptideAtlas

More...
PeptideAtlasi
Q15366

PRoteomics IDEntifications database

More...
PRIDEi
Q15366

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
32176
5458
60542 [Q15366-1]
60543 [Q15366-2]
60544 [Q15366-3]
60545 [Q15366-4]
60546 [Q15366-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q15366

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q15366

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q15366

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in all tissues examined.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000197111 Expressed in 232 organ(s), highest expression level in right testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q15366 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q15366 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA038356

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1.

Interacts with IFIH1 and RNF135.

Interacts with MAVS (via C-terminus) and ITCH (via WW domains).

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111127, 126 interactors

Database of interacting proteins

More...
DIPi
DIP-58934N

Protein interaction database and analysis system

More...
IntActi
Q15366, 59 interactors

Molecular INTeraction database

More...
MINTi
Q15366

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000352438

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1365
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q15366

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q15366

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini13 – 75KH 1PROSITE-ProRule annotationAdd BLAST63
Domaini97 – 162KH 2PROSITE-ProRule annotationAdd BLAST66
Domaini287 – 351KH 3PROSITE-ProRule annotationAdd BLAST65

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The KH domains mediates poly(C) binding.

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2190 Eukaryota
ENOG410XNN8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154129

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000182823

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q15366

KEGG Orthology (KO)

More...
KOi
K13162

Identification of Orthologs from Complete Genome Data

More...
OMAi
EECNRMA

Database of Orthologous Groups

More...
OrthoDBi
954970at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q15366

TreeFam database of animal gene trees

More...
TreeFami
TF318292

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1370.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00013 KH_1, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00322 KH, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54791 SSF54791, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50084 KH_TYPE_1, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 8 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15366-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDTGVIEGGL NVTLTIRLLM HGKEVGSIIG KKGESVKKMR EESGARINIS
60 70 80 90 100
EGNCPERIIT LAGPTNAIFK AFAMIIDKLE EDISSSMTNS TAASRPPVTL
110 120 130 140 150
RLVVPASQCG SLIGKGGCKI KEIRESTGAQ VQVAGDMLPN STERAITIAG
160 170 180 190 200
IPQSIIECVK QICVVMLETL SQSPPKGVTI PYRPKPSSSP VIFAGGQDRY
210 220 230 240 250
STGSDSASFP HTTPSMCLNP DLEGPPLEAY TIQGQYAIPQ PDLTKLHQLA
260 270 280 290 300
MQQSHFPMTH GNTGFSGIES SSPEVKGYWG LDASAQTTSH ELTIPNDLIG
310 320 330 340 350
CIIGRQGAKI NEIRQMSGAQ IKIANPVEGS TDRQVTITGS AASISLAQYL
360
INVRLSSETG GMGSS
Length:365
Mass (Da):38,580
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i43F035D76FDC2C63
GO
Isoform 2 (identifier: Q15366-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     279-279: W → WA

Note: No experimental confirmation available.
Show »
Length:366
Mass (Da):38,651
Checksum:i3464C973504D90DE
GO
Isoform 3 (identifier: Q15366-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     169-172: Missing.
     279-279: W → WA

Show »
Length:362
Mass (Da):38,222
Checksum:i70C8AF710E3BF3C0
GO
Isoform 4 (identifier: Q15366-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     169-172: Missing.
     198-228: Missing.
     279-279: W → WA

Note: No experimental confirmation available.
Show »
Length:331
Mass (Da):34,917
Checksum:iE831D4BF718C26E3
GO
Isoform 5 (identifier: Q15366-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     198-228: Missing.
     279-279: W → WA

Note: No experimental confirmation available.
Show »
Length:335
Mass (Da):35,347
Checksum:iBD1A8AA65EABF0BF
GO
Isoform 6 (identifier: Q15366-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     169-172: Missing.

Note: No experimental confirmation available.
Show »
Length:361
Mass (Da):38,151
Checksum:i4F96378919BF3215
GO
Isoform 7 (identifier: Q15366-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     169-172: Missing.
     198-228: Missing.
     267-279: GIESSSPEVKGYW → A

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:318
Mass (Da):33,497
Checksum:iB5B41191CFD1B171
GO
Isoform 8 (identifier: Q15366-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     198-228: Missing.
     267-279: GIESSSPEVKGYW → A

Note: No experimental confirmation available.
Show »
Length:322
Mass (Da):33,926
Checksum:i7DDD51D4F8BEB977
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BSS4H3BSS4_HUMAN
Poly(rC)-binding protein 2
PCBP2
184Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VRH0F8VRH0_HUMAN
Poly(rC)-binding protein 2
PCBP2
310Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W1G6F8W1G6_HUMAN
Poly(rC)-binding protein 2
PCBP2
202Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VZX2F8VZX2_HUMAN
Poly(rC)-binding protein 2
PCBP2
321Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VTZ0F8VTZ0_HUMAN
Poly(rC)-binding protein 2
PCBP2
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VXH9F8VXH9_HUMAN
Poly(rC)-binding protein 2
PCBP2
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W0G4F8W0G4_HUMAN
Poly(rC)-binding protein 2
PCBP2
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BRU6H3BRU6_HUMAN
Poly(rC)-binding protein 2
PCBP2
301Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BND9H3BND9_HUMAN
Poly(rC)-binding protein 2
PCBP2
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BSP4H3BSP4_HUMAN
Poly(rC)-binding protein 2
PCBP2
36Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD92062 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_043161169 – 172Missing in isoform 3, isoform 4, isoform 6 and isoform 7. 4 Publications4
Alternative sequenceiVSP_043362198 – 228Missing in isoform 4, isoform 5, isoform 7 and isoform 8. 3 PublicationsAdd BLAST31
Alternative sequenceiVSP_054045267 – 279GIESS…VKGYW → A in isoform 7 and isoform 8. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_042833279W → WA in isoform 2, isoform 3, isoform 4 and isoform 5. 3 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X78136 mRNA Translation: CAA55015.1
AB188306 mRNA Translation: BAD36897.1
AK292141 mRNA Translation: BAF84830.1
AK302067 mRNA Translation: BAG63457.1
AB208825 mRNA Translation: BAD92062.1 Different initiation.
AC023509 Genomic DNA No translation available.
AC068889 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW96706.1
CH471054 Genomic DNA Translation: EAW96707.1
CH471054 Genomic DNA Translation: EAW96709.1
CH471054 Genomic DNA Translation: EAW96711.1
BC001155 mRNA Translation: AAH01155.1
BC071942 mRNA Translation: AAH71942.1
BC107688 mRNA Translation: AAI07689.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44900.1 [Q15366-2]
CCDS44901.1 [Q15366-1]
CCDS44902.1 [Q15366-5]
CCDS44903.1 [Q15366-4]
CCDS44904.1 [Q15366-7]
CCDS55830.1 [Q15366-6]
CCDS8859.1 [Q15366-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
S65679 S42471

NCBI Reference Sequences

More...
RefSeqi
NP_001092090.1, NM_001098620.2 [Q15366-4]
NP_001122383.1, NM_001128911.1 [Q15366-1]
NP_001122384.1, NM_001128912.1 [Q15366-6]
NP_001122385.1, NM_001128913.1 [Q15366-5]
NP_001122386.1, NM_001128914.1 [Q15366-7]
NP_005007.2, NM_005016.5 [Q15366-2]
NP_114366.1, NM_031989.4 [Q15366-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000359282; ENSP00000352228; ENSG00000197111 [Q15366-4]
ENST00000359462; ENSP00000352438; ENSG00000197111 [Q15366-2]
ENST00000437231; ENSP00000390304; ENSG00000197111 [Q15366-7]
ENST00000439930; ENSP00000408949; ENSG00000197111 [Q15366-1]
ENST00000447282; ENSP00000394116; ENSG00000197111 [Q15366-5]
ENST00000455667; ENSP00000388008; ENSG00000197111 [Q15366-7]
ENST00000546463; ENSP00000448762; ENSG00000197111 [Q15366-3]
ENST00000548933; ENSP00000449062; ENSG00000197111 [Q15366-5]
ENST00000552296; ENSP00000448927; ENSG00000197111 [Q15366-6]
ENST00000552819; ENSP00000449070; ENSG00000197111 [Q15366-8]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5094

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5094

UCSC genome browser

More...
UCSCi
uc001sdb.5 human [Q15366-1]
uc058oqk.1 human

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78136 mRNA Translation: CAA55015.1
AB188306 mRNA Translation: BAD36897.1
AK292141 mRNA Translation: BAF84830.1
AK302067 mRNA Translation: BAG63457.1
AB208825 mRNA Translation: BAD92062.1 Different initiation.
AC023509 Genomic DNA No translation available.
AC068889 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW96706.1
CH471054 Genomic DNA Translation: EAW96707.1
CH471054 Genomic DNA Translation: EAW96709.1
CH471054 Genomic DNA Translation: EAW96711.1
BC001155 mRNA Translation: AAH01155.1
BC071942 mRNA Translation: AAH71942.1
BC107688 mRNA Translation: AAI07689.1
CCDSiCCDS44900.1 [Q15366-2]
CCDS44901.1 [Q15366-1]
CCDS44902.1 [Q15366-5]
CCDS44903.1 [Q15366-4]
CCDS44904.1 [Q15366-7]
CCDS55830.1 [Q15366-6]
CCDS8859.1 [Q15366-3]
PIRiS65679 S42471
RefSeqiNP_001092090.1, NM_001098620.2 [Q15366-4]
NP_001122383.1, NM_001128911.1 [Q15366-1]
NP_001122384.1, NM_001128912.1 [Q15366-6]
NP_001122385.1, NM_001128913.1 [Q15366-5]
NP_001122386.1, NM_001128914.1 [Q15366-7]
NP_005007.2, NM_005016.5 [Q15366-2]
NP_114366.1, NM_031989.4 [Q15366-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AXYX-ray1.70A/B/C/D11-82[»]
2JZXNMR-A11-169[»]
2P2RX-ray1.60A285-359[»]
2PQUX-ray2.12A/B/C/D11-82[»]
2PY9X-ray2.56A/B/C/D11-82[»]
SMRiQ15366
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi111127, 126 interactors
DIPiDIP-58934N
IntActiQ15366, 59 interactors
MINTiQ15366
STRINGi9606.ENSP00000352438

PTM databases

iPTMnetiQ15366
PhosphoSitePlusiQ15366
SwissPalmiQ15366

Polymorphism and mutation databases

BioMutaiPCBP2
DMDMi6707736

Proteomic databases

EPDiQ15366
jPOSTiQ15366
MassIVEiQ15366
MaxQBiQ15366
PaxDbiQ15366
PeptideAtlasiQ15366
PRIDEiQ15366
ProteomicsDBi32176
5458
60542 [Q15366-1]
60543 [Q15366-2]
60544 [Q15366-3]
60545 [Q15366-4]
60546 [Q15366-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5094

Genome annotation databases

EnsembliENST00000359282; ENSP00000352228; ENSG00000197111 [Q15366-4]
ENST00000359462; ENSP00000352438; ENSG00000197111 [Q15366-2]
ENST00000437231; ENSP00000390304; ENSG00000197111 [Q15366-7]
ENST00000439930; ENSP00000408949; ENSG00000197111 [Q15366-1]
ENST00000447282; ENSP00000394116; ENSG00000197111 [Q15366-5]
ENST00000455667; ENSP00000388008; ENSG00000197111 [Q15366-7]
ENST00000546463; ENSP00000448762; ENSG00000197111 [Q15366-3]
ENST00000548933; ENSP00000449062; ENSG00000197111 [Q15366-5]
ENST00000552296; ENSP00000448927; ENSG00000197111 [Q15366-6]
ENST00000552819; ENSP00000449070; ENSG00000197111 [Q15366-8]
GeneIDi5094
KEGGihsa:5094
UCSCiuc001sdb.5 human [Q15366-1]
uc058oqk.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5094
DisGeNETi5094

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PCBP2
HGNCiHGNC:8648 PCBP2
HPAiHPA038356
MIMi601210 gene
neXtProtiNX_Q15366
OpenTargetsiENSG00000197111
PharmGKBiPA32987

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2190 Eukaryota
ENOG410XNN8 LUCA
GeneTreeiENSGT00940000154129
HOGENOMiHOG000182823
InParanoidiQ15366
KOiK13162
OMAiEECNRMA
OrthoDBi954970at2759
PhylomeDBiQ15366
TreeFamiTF318292

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PCBP2 human
EvolutionaryTraceiQ15366

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PCBP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5094
PharosiQ15366

Protein Ontology

More...
PROi
PR:Q15366

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000197111 Expressed in 232 organ(s), highest expression level in right testis
ExpressionAtlasiQ15366 baseline and differential
GenevisibleiQ15366 HS

Family and domain databases

Gene3Di3.30.1370.10, 3 hits
InterProiView protein in InterPro
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
PfamiView protein in Pfam
PF00013 KH_1, 3 hits
SMARTiView protein in SMART
SM00322 KH, 3 hits
SUPFAMiSSF54791 SSF54791, 3 hits
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPCBP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15366
Secondary accession number(s): A8K7X6
, B4DXP5, F8VYL7, G3V0E8, I6L8F9, Q32Q82, Q59HD4, Q68Y55, Q6IPF4, Q6PKG5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: October 16, 2019
This is version 193 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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