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Entry version 66 (08 May 2019)
Sequence version 2 (24 Jun 2015)
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Protein

Telomerase reverse transcriptase

Gene

tert

Organism
Oryzias latipes (Japanese rice fish) (Japanese killifish)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi666Magnesium; catalyticPROSITE-ProRule annotation1
Metal bindingi826Magnesium; catalyticPROSITE-ProRule annotation1
Metal bindingi827Magnesium; catalyticPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, Ribonucleoprotein, RNA-binding, RNA-directed DNA polymerase, Transferase
LigandMagnesium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Telomerase reverse transcriptase1 Publication (EC:2.7.7.49PROSITE-ProRule annotation2 Publications)
Alternative name(s):
Telomerase catalytic subunitCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tert1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOryzias latipes (Japanese rice fish) (Japanese killifish)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeBeloniformesAdrianichthyidaeOryziinaeOryzias
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001038 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11
  • UP000265180 Componenti: Unplaced
  • UP000265200 Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi355F → L: Mildly impaired RNA template binding. 1 Publication1
Mutagenesisi355F → Y: Impaired RNA template binding. 1 Publication1
Mutagenesisi376F → A: Impaired RNA template binding. 1 Publication1
Mutagenesisi477W → F: No effect on RNA template binding. 1 Publication1
Mutagenesisi477W → L: Impaired RNA template binding. 1 Publication1
Mutagenesisi503Y → A: Impaired RNA template binding. 1 Publication1
Mutagenesisi503Y → F: No effect on RNA template binding. 1 Publication1
Mutagenesisi503Y → S: Impaired RNA template binding. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004333911 – 1090Telomerase reverse transcriptaseCuratedAdd BLAST1090

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at highest levels in gonads and brain, and at lower levels in heart, spleen, kidney, gill, muscle and skin (PubMed:18312429, PubMed:21547060). Detected in embryonic stem cell lines before and after differentiation (PubMed:21547060). Isoform F is expressed in gonads, with higher levels in testis relative to ovary, but is not detected in other tissues (PubMed:18312429). Isoform B is expressed predominantly in testis (PubMed:21547060). Isoform C is up-regulated in embryonic stem cell lines after differentiation (PubMed:21547060).2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed at high levels from the embryonic 2-cell stage through to the blastula stage, possibly due to inheritance of maternal transcripts. During later stages levels gradually decline.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Catalytic subunit of the telomerase holoenzyme complex composed minimally of TERT and the telomerase RNA template component (TERC).

2 Publications

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
8090.ENSORLP00000017467

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11090
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q1PS67

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini569 – 893Reverse transcriptasePROSITE-ProRule annotationAdd BLAST325

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni371 – 376Interaction with RNA template1 Publication6
Regioni477 – 503Interaction with RNA template1 PublicationAdd BLAST27

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi316 – 321TFLY; involved in RNA bindingBy similarity6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1005 Eukaryota
ENOG410XQJH LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018531

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000148780

KEGG Orthology (KO)

More...
KOi
K11126

Database of Orthologous Groups

More...
OrthoDBi
1297956at2759

TreeFam database of animal gene trees

More...
TreeFami
TF329048

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000477 RT_dom
IPR021891 Telomerase_RBD
IPR003545 Telomerase_RT

The PANTHER Classification System

More...
PANTHERi
PTHR12066 PTHR12066, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00078 RVT_1, 1 hit
PF12009 Telomerase_RBD, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01365 TELOMERASERT

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00975 Telomerase_RBD, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50878 RT_POL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform A1 Publication (identifier: Q1PS67-1) [UniParc]FASTAAdd to basket
Also known as: Long1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTSGDLSSVL NILRSLYKRT RTLEEFADGV VFREGRRAAL LQPSDTHSFK
60 70 80 90 100
SFVRGVFVCS DEELQDVPSC NQTCTFPELL AFILNSLKRK RRRNVLAHGY
110 120 130 140 150
NFLGVAQEDR DADHFRFQGD LSQSAAYIHS SDLWKKVTAR LGTDVTRYLL
160 170 180 190 200
GSCSVFVLAP PSCVFQICGV PAYDRVSMTT ASSGFLLRPP SRKHKSFQVG
210 220 230 240 250
KKTRSANLTK TGSVGDVEES RKRRRVESEV STRKRKRESE EEESRERRRG
260 270 280 290 300
VHHEERRQHE AVLDESTLSG KSGENDAAAV KPPPETSAAP PPLEGGPSWR
310 320 330 340 350
SGAFPPLPSS QCFIRTLGFL YGGRGMHGFC LNRKRRTAAG PRRLQGQDLV
360 370 380 390 400
RLVFFEGLPY LNGQERKPKK LPLRYFNMVP VFGRLLQRHR KCRYSSVLHR
410 420 430 440 450
MCPVVELSRA AQGELSSLIP QHCAPHRVYL FVRECLTAVV PEELWGSDHN
460 470 480 490 500
RLQFFSRVRG FLKSGKFERI SVAELMWKIK VMDCDWLKLR RTAGRFPPSE
510 520 530 540 550
LAYRTRILSQ FLTWLLDGFV VGLVRACFYA TESVGQKNAI RFYRQEVWSK
560 570 580 590 600
LQDLAFRRHI AKGEMEELSP AQVASLPKGT VISQLRFIPK TDGMRPITRV
610 620 630 640 650
IGADSNTRLH HKRIRDLMSM LQARVRSAPA LLGSTVWGMT DIHKVLRSLA
660 670 680 690 700
PAQKDKPQPL YFVKVDVSGA YDSLPHDKLK EVITEALSPV QEEVFTVRHY
710 720 730 740 750
AKIWADSHEG LKKAFARQVD FSDGSMGSTS MKGFVMSLQK SSKVHHAVLV
760 770 780 790 800
EQAFGSNLRG KDALQFFTQM LTGSVVQHGK KTYRQCRGIP QGSVVSSLLC
810 820 830 840 850
CLCYGHMENV LFRDIKNKGW LMRLVDDFLL ITPDRNQAQS FLSILLAGVP
860 870 880 890 900
QYGVVANPQK VVVNFQGSEG GGAFPDIRVL PPHCLFPWCG LLLDTRSLDV
910 920 930 940 950
CKDYSSYAGL SLRYSLTLGS AHSAGQQMRR KLMSILRIKC HPLFLDLKTN
960 970 980 990 1000
SLESAYKNIH KLVLLQACRF HVCVQSLPFA QTVAKNPTYF QQMIWDMAHY
1010 1020 1030 1040 1050
ANALIRRSNT GLVLGDGAQK GSVQYEAVEL LFCLAFLRVL SKHRPVYKDL
1060 1070 1080 1090
LPRLHKWKRR LERLLGDLRL ARVRQAANPR ALLDFLAMQM
Length:1,090
Mass (Da):123,387
Last modified:June 24, 2015 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDF885F35FD57ADAB
GO
Isoform B1 Publication (identifier: Q1PS67-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     73-444: TCTFPELLAF...CLTAVVPEEL → VDFSDGSMGS...ALLDFLAMQM
     445-1090: Missing.

Show »
Length:444
Mass (Da):49,832
Checksum:iC4B3F8E64B3EC949
GO
Isoform C1 Publication (identifier: Q1PS67-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     609-619: LHHKRIRDLMS → VHTDEISSVLS
     620-1090: Missing.

Show »
Length:619
Mass (Da):70,269
Checksum:iC1831EDB25BE637D
GO
Isoform D1 Publication (identifier: Q1PS67-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     666-690: DVSGAYDSLPHDKLKEVITEALSPV → NLVLPGTSDVFLSPPVSDGLTCGLG
     691-1090: Missing.

Show »
Length:690
Mass (Da):78,030
Checksum:i5976630CFD0C44C6
GO
Isoform E1 Publication (identifier: Q1PS67-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     609-666: LHHKRIRDLM...PQPLYFVKVD → EHPMFSFLHP...RGSLHRPPLR
     667-1090: Missing.

Show »
Length:666
Mass (Da):75,559
Checksum:iC2F31D606E97B2B4
GO
Isoform FCurated (identifier: Q1PS67-6) [UniParc]FASTAAdd to basket
Also known as: Short1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1057-1063: WKRRLER → CGCSTKH
     1064-1090: Missing.

Show »
Length:1,063
Mass (Da):120,043
Checksum:iFDE3F232E169539F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140TAW2A0A140TAW2_ORYLA
Telomerase reverse transcriptase
tert
1,090Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti164V → I in ABB76648 (PubMed:18312429).1
Sequence conflicti164V → I in ADZ28508 (Ref. 3) 1
Sequence conflicti164V → I in ADZ28509 (Ref. 3) 1
Sequence conflicti164V → I in ADZ28510 (Ref. 3) 1
Sequence conflicti164V → I in ADZ28511 (Ref. 3) 1
Sequence conflicti203T → R in ABB76648 (PubMed:18312429).1
Sequence conflicti203T → R in ADZ28508 (Ref. 3) 1
Sequence conflicti203T → R in ADZ28509 (Ref. 3) 1
Sequence conflicti203T → R in ADZ28510 (Ref. 3) 1
Sequence conflicti203T → R in ADZ28511 (Ref. 3) 1
Sequence conflicti211T → R in ABB76648 (PubMed:18312429).1
Sequence conflicti211T → R in ADZ28508 (Ref. 3) 1
Sequence conflicti211T → R in ADZ28509 (Ref. 3) 1
Sequence conflicti211T → R in ADZ28511 (Ref. 3) 1
Sequence conflicti229E → G in ABB76648 (PubMed:18312429).1
Sequence conflicti229E → G in ADZ28508 (Ref. 3) 1
Sequence conflicti229E → G in ADZ28509 (Ref. 3) 1
Sequence conflicti229E → G in ADZ28511 (Ref. 3) 1
Sequence conflicti232T → A in ABB76648 (PubMed:18312429).1
Sequence conflicti232T → A in ADZ28508 (Ref. 3) 1
Sequence conflicti232T → A in ADZ28509 (Ref. 3) 1
Sequence conflicti232T → A in ADZ28511 (Ref. 3) 1
Sequence conflicti239S → P in ABB76648 (PubMed:18312429).1
Sequence conflicti239S → P in ADZ28508 (Ref. 3) 1
Sequence conflicti239S → P in ADZ28509 (Ref. 3) 1
Sequence conflicti239S → P in ADZ28511 (Ref. 3) 1
Sequence conflicti820W → C in ABB76648 (PubMed:18312429).1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05776473 – 444TCTFP…VPEEL → VDFSDGSMGSTSMKGFVMSL QKSSKVHHAVLVEQAFGSNL RGKDALQFFTQMLTGSVVQH GKKTYRQCRGIPQGSVVSSL LCCLCYGHMENVLFRDIKNK GCLMRLVDDFLLITPDRNQA QSFLSILLAGVPQYGVVANP QKVVVNFQGSEGGGAFPDIR VLPPHCLFPWCGLLLDTRSL DVCKDYSSYAGLSLRYSLTL GSAHSAGQQMRRKLMSILRI KCHPLFLDLKTNSLESAYKN IHKLVLLQACRFHVCVQSLP FAQTVAKNPTYFQQMIWDMA HYANALIRRSNTGLVLGDGA QKGSVQYEAVELLFCLAFLR VLSKHRPVYKDLLPRLHKWK RRLERLLGDLRLARVRQAAN PRALLDFLAMQM in isoform B. Add BLAST372
Alternative sequenceiVSP_057765445 – 1090Missing in isoform B. Add BLAST646
Alternative sequenceiVSP_057766609 – 666LHHKR…FVKVD → EHPMFSFLHPSLTGSPVGWA EGGCERRLRQSAARQTQGGD HRGFVTRPRGSLHRPPLR in isoform E. Add BLAST58
Alternative sequenceiVSP_057767609 – 619LHHKRIRDLMS → VHTDEISSVLS in isoform C. Add BLAST11
Alternative sequenceiVSP_057768620 – 1090Missing in isoform C. Add BLAST471
Alternative sequenceiVSP_057769666 – 690DVSGA…ALSPV → NLVLPGTSDVFLSPPVSDGL TCGLG in isoform D. Add BLAST25
Alternative sequenceiVSP_057770667 – 1090Missing in isoform E. Add BLAST424
Alternative sequenceiVSP_057771691 – 1090Missing in isoform D. Add BLAST400
Alternative sequenceiVSP_0577721057 – 1063WKRRLER → CGCSTKH in isoform F. 7
Alternative sequenceiVSP_0577731064 – 1090Missing in isoform F. Add BLAST27

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
DQ248968 mRNA Translation: ABB76648.1
DQ870623 mRNA Translation: ABI74619.1
JF326825 mRNA Translation: ADZ28508.1
JF326826 mRNA Translation: ADZ28509.1
JF326827 mRNA Translation: ADZ28510.1
JF326828 mRNA Translation: ADZ28511.1

NCBI Reference Sequences

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RefSeqi
NP_001098286.1, NM_001104816.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSORLT00000035913; ENSORLP00000030497; ENSORLG00000013929 [Q1PS67-2]
ENSORLT00000044664; ENSORLP00000033801; ENSORLG00000013929 [Q1PS67-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
100049443

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
ola:100049443

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ248968 mRNA Translation: ABB76648.1
DQ870623 mRNA Translation: ABI74619.1
JF326825 mRNA Translation: ADZ28508.1
JF326826 mRNA Translation: ADZ28509.1
JF326827 mRNA Translation: ADZ28510.1
JF326828 mRNA Translation: ADZ28511.1
RefSeqiNP_001098286.1, NM_001104816.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4O26X-ray3.00A/B318-572[»]
SMRiQ1PS67
ModBaseiSearch...

Protein-protein interaction databases

STRINGi8090.ENSORLP00000017467

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSORLT00000035913; ENSORLP00000030497; ENSORLG00000013929 [Q1PS67-2]
ENSORLT00000044664; ENSORLP00000033801; ENSORLG00000013929 [Q1PS67-5]
GeneIDi100049443
KEGGiola:100049443

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7015

Phylogenomic databases

eggNOGiKOG1005 Eukaryota
ENOG410XQJH LUCA
GeneTreeiENSGT00390000018531
HOGENOMiHOG000148780
KOiK11126
OrthoDBi1297956at2759
TreeFamiTF329048

Family and domain databases

InterProiView protein in InterPro
IPR000477 RT_dom
IPR021891 Telomerase_RBD
IPR003545 Telomerase_RT
PANTHERiPTHR12066 PTHR12066, 1 hit
PfamiView protein in Pfam
PF00078 RVT_1, 1 hit
PF12009 Telomerase_RBD, 1 hit
PRINTSiPR01365 TELOMERASERT
SMARTiView protein in SMART
SM00975 Telomerase_RBD, 1 hit
PROSITEiView protein in PROSITE
PS50878 RT_POL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTERT_ORYLA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q1PS67
Secondary accession number(s): A7J3B2
, H2BIT2, H2BIT3, H2BIT4, H2BIT5, H2MFU0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 24, 2015
Last sequence update: June 24, 2015
Last modified: May 8, 2019
This is version 66 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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