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Entry version 130 (11 Dec 2019)
Sequence version 3 (01 May 2007)
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Protein

Peroxisomal leader peptide-processing protease

Gene

TYSND1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei372Charge relay systemBy similarity1
Active sitei408Charge relay systemBy similarity1
Active sitei481Charge relay systemBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protease binding Source: UniProtKB
  • serine-type endopeptidase activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-9033241 Peroxisomal protein import
R-HSA-9033500 TYSND1 cleaves peroxisomal proteins

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S01.286

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peroxisomal leader peptide-processing protease (EC:3.4.21.-)
Alternative name(s):
Trypsin domain-containing protein 1
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TYSND1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000156521.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28531 TYSND1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611017 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q2T9J0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi481S → A: Abrogates the self-cleaving activity of TYSND1. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
219743

Open Targets

More...
OpenTargetsi
ENSG00000156521

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134968651

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q2T9J0 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TYSND1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
146325807

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002861241 – 566Peroxisomal leader peptide-processing proteaseAdd BLAST566
ChainiPRO_00002861251 – 110Peroxisomal leader peptide-processing protease, 15 kDa formAdd BLAST110
ChainiPRO_0000286126111 – 566Peroxisomal leader peptide-processing protease, 45 kDa formAdd BLAST456

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Self-cleavage gives rise to an N-terminal 15-kDa fragment and C-terminal 45-kDa fragment upon import into the peroxisomes. The full-lengh TYSND1 is the active the proteolytic processing of PTS1- and PTS2-proteins and in self-cleavage, and intermolecular self-cleavage of TYSND1 down-regulates its protease activity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei110 – 111CleavageBy similarity2

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q2T9J0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q2T9J0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q2T9J0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q2T9J0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q2T9J0

PeptideAtlas

More...
PeptideAtlasi
Q2T9J0

PRoteomics IDEntifications database

More...
PRIDEi
Q2T9J0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
61444 [Q2T9J0-1]
61445 [Q2T9J0-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q2T9J0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q2T9J0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000156521 Expressed in 145 organ(s), highest expression level in testis

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q2T9J0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA030304

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Forms a heterodimer with the C-terminal cleavage product (45 kDa form).

Forms a heterodimer with the N-terminal cleavage product (15 kDa form).

Interacts with PEX5.

Interacts with LONP2.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
128571, 14 interactors

Protein interaction database and analysis system

More...
IntActi
Q2T9J0, 17 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000287078

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q2T9J0 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q2T9J0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni319 – 531Serine proteaseAdd BLAST213

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S1B family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1320 Eukaryota
COG0265 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000014627

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000050236

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q2T9J0

KEGG Orthology (KO)

More...
KOi
K23012

Identification of Orthologs from Complete Genome Data

More...
OMAi
CHGGIFT

Database of Orthologous Groups

More...
OrthoDBi
1307240at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q2T9J0

TreeFam database of animal gene trees

More...
TreeFami
TF331254

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017345 Pept_S1A_Tysnd1
IPR009003 Peptidase_S1_PA
IPR039245 TYSND1/DEG15

The PANTHER Classification System

More...
PANTHERi
PTHR21004 PTHR21004, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037989 Peptidase_S1B_Tysnd1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50494 SSF50494, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q2T9J0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRRQWGSAMR AAEQAGCMVS ASRAGQPEAG PWSCSGVILS RSPGLVLCHG
60 70 80 90 100
GIFVPFLRAG SEVLTAAGAV FLPGDSCRDD LRLHVQWAPT AAGPGGGAER
110 120 130 140 150
GRPGLCTPQC ASLEPGPPAP SRGRPLQPRL PAELLLLLSC PAFWAHFARL
160 170 180 190 200
FGDEAAEQWR FSSAARDDEV SEDEEADQLR ALGWFALLGV RLGQEEVEEE
210 220 230 240 250
RGPAMAVSPL GAVPKGAPLL VCGSPFGAFC PDIFLNTLSC GVLSNVAGPL
260 270 280 290 300
LLTDARCLPG TEGGGVFTAR PAGALVALVV APLCWKAGEW VGFTLLCAAA
310 320 330 340 350
PLFRAARDAL HRLPHSTAAL AALLPPEVGV PWGLPLRDSG PLWAAAAVLV
360 370 380 390 400
ECGTVWGSGV AVAPRLVVTC RHVSPREAAR VLVRSTTPKS VAIWGRVVFA
410 420 430 440 450
TQETCPYDIA VVSLEEDLDD VPIPVPAEHF HEGEAVSVVG FGVFGQSCGP
460 470 480 490 500
SVTSGILSAV VQVNGTPVML QTTCAVHSGS SGGPLFSNHS GNLLGIITSN
510 520 530 540 550
TRDNNTGATY PHLNFSIPIT VLQPALQQYS QTQDLGGLRE LDRAAEPVRV
560
VWRLQRPLAE APRSKL
Length:566
Mass (Da):59,309
Last modified:May 1, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i530B895B8698F2E6
GO
Isoform 2 (identifier: Q2T9J0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     390-398: SVAIWGRVV → HNHQQHPGQ
     399-566: Missing.

Show »
Length:398
Mass (Da):41,573
Checksum:iE7AC4EFD235D465F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti203P → L in AAH30242 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05975865T → A1 PublicationCorresponds to variant dbSNP:rs4746970Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_025000390 – 398SVAIWGRVV → HNHQQHPGQ in isoform 2. 1 Publication9
Alternative sequenceiVSP_025001399 – 566Missing in isoform 2. 1 PublicationAdd BLAST168

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL731540 Genomic DNA No translation available.
BC016840 mRNA Translation: AAH16840.1
BC030242 mRNA Translation: AAH30242.1
BC111501 mRNA Translation: AAI11502.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31213.1 [Q2T9J0-1]
CCDS31214.1 [Q2T9J0-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001035363.1, NM_001040273.2 [Q2T9J0-2]
NP_775826.2, NM_173555.3 [Q2T9J0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000287078; ENSP00000287078; ENSG00000156521 [Q2T9J0-1]
ENST00000335494; ENSP00000335673; ENSG00000156521 [Q2T9J0-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
219743

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:219743

UCSC genome browser

More...
UCSCi
uc001jqr.5 human [Q2T9J0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL731540 Genomic DNA No translation available.
BC016840 mRNA Translation: AAH16840.1
BC030242 mRNA Translation: AAH30242.1
BC111501 mRNA Translation: AAI11502.2
CCDSiCCDS31213.1 [Q2T9J0-1]
CCDS31214.1 [Q2T9J0-2]
RefSeqiNP_001035363.1, NM_001040273.2 [Q2T9J0-2]
NP_775826.2, NM_173555.3 [Q2T9J0-1]

3D structure databases

SMRiQ2T9J0
ModBaseiSearch...

Protein-protein interaction databases

BioGridi128571, 14 interactors
IntActiQ2T9J0, 17 interactors
STRINGi9606.ENSP00000287078

Protein family/group databases

MEROPSiS01.286

PTM databases

iPTMnetiQ2T9J0
PhosphoSitePlusiQ2T9J0

Polymorphism and mutation databases

BioMutaiTYSND1
DMDMi146325807

Proteomic databases

EPDiQ2T9J0
jPOSTiQ2T9J0
MassIVEiQ2T9J0
MaxQBiQ2T9J0
PaxDbiQ2T9J0
PeptideAtlasiQ2T9J0
PRIDEiQ2T9J0
ProteomicsDBi61444 [Q2T9J0-1]
61445 [Q2T9J0-2]

Genome annotation databases

EnsembliENST00000287078; ENSP00000287078; ENSG00000156521 [Q2T9J0-1]
ENST00000335494; ENSP00000335673; ENSG00000156521 [Q2T9J0-2]
GeneIDi219743
KEGGihsa:219743
UCSCiuc001jqr.5 human [Q2T9J0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
219743
DisGeNETi219743
EuPathDBiHostDB:ENSG00000156521.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TYSND1
HGNCiHGNC:28531 TYSND1
HPAiHPA030304
MIMi611017 gene
neXtProtiNX_Q2T9J0
OpenTargetsiENSG00000156521
PharmGKBiPA134968651

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1320 Eukaryota
COG0265 LUCA
GeneTreeiENSGT00390000014627
HOGENOMiHOG000050236
InParanoidiQ2T9J0
KOiK23012
OMAiCHGGIFT
OrthoDBi1307240at2759
PhylomeDBiQ2T9J0
TreeFamiTF331254

Enzyme and pathway databases

ReactomeiR-HSA-9033241 Peroxisomal protein import
R-HSA-9033500 TYSND1 cleaves peroxisomal proteins

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TYSND1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
219743
PharosiQ2T9J0 Tbio

Protein Ontology

More...
PROi
PR:Q2T9J0
RNActiQ2T9J0 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000156521 Expressed in 145 organ(s), highest expression level in testis
GenevisibleiQ2T9J0 HS

Family and domain databases

InterProiView protein in InterPro
IPR017345 Pept_S1A_Tysnd1
IPR009003 Peptidase_S1_PA
IPR039245 TYSND1/DEG15
PANTHERiPTHR21004 PTHR21004, 1 hit
PIRSFiPIRSF037989 Peptidase_S1B_Tysnd1, 1 hit
SUPFAMiSSF50494 SSF50494, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTYSD1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2T9J0
Secondary accession number(s): Q5SQT4
, Q5SQU1, Q8N6H2, Q96AR5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: December 11, 2019
This is version 130 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Peptidase families
    Classification of peptidase families and list of entries
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