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Entry version 122 (16 Oct 2019)
Sequence version 3 (05 Apr 2011)
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Protein

Formin-1

Gene

FMN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the formation of adherens junction and the polymerization of linear actin cables.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Formin-1
Alternative name(s):
Limb deformity protein homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FMN1
Synonyms:FMN, LD
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3768 FMN1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
136535 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q68DA7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
342184

Open Targets

More...
OpenTargetsi
ENSG00000248905

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q68DA7

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FMN1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
327478585

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002963611 – 1419Formin-1Add BLAST1419

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on serine and possibly threonine residues.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q68DA7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q68DA7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q68DA7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q68DA7

PeptideAtlas

More...
PeptideAtlasi
Q68DA7

PRoteomics IDEntifications database

More...
PRIDEi
Q68DA7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
66065 [Q68DA7-1]
66066 [Q68DA7-2]
66067 [Q68DA7-3]
66068 [Q68DA7-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q68DA7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q68DA7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in fetal kidney and fetal lung.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000248905 Expressed in 117 organ(s), highest expression level in kidney

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q68DA7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q68DA7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA005465
HPA046786

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with alpha-catenin and may interact with tubulin.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
131167, 7 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q68DA7

Protein interaction database and analysis system

More...
IntActi
Q68DA7, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000479134

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q68DA7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini870 – 957FH1Add BLAST88
Domaini972 – 1388FH2PROSITE-ProRule annotationAdd BLAST417

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 622Microtubule-bindingBy similarityAdd BLAST622
Regioni456 – 842Mediates interaction with alpha-cateninBy similarityAdd BLAST387

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili720 – 774Sequence analysisAdd BLAST55

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi869 – 984Pro-richAdd BLAST116

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1922 Eukaryota
ENOG411149J LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154289

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112617

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q68DA7

KEGG Orthology (KO)

More...
KOi
K10367

Identification of Orthologs from Complete Genome Data

More...
OMAi
GFNEQTP

Database of Orthologous Groups

More...
OrthoDBi
249504at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q68DA7

TreeFam database of animal gene trees

More...
TreeFami
TF326072

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.58.2220, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015425 FH2_Formin
IPR042201 FH2_Formin_sf
IPR001265 Formin_Cappuccino_subfam

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02181 FH2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00828 FORMIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00498 FH2, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51444 FH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q68DA7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGTHCTLQL HKPITELCYI SFCLPKGEVR GFSYKGTVTL DRSNKGFHNC
60 70 80 90 100
YQVREESDII SLSQEPDEHP GDIFFKQTPT KDILTELYKL TTERERLLTN
110 120 130 140 150
LLSSDHILGI TMGNQEGKLQ ELSVSLAPED DCFQSAGDWQ GELPVGPLNK
160 170 180 190 200
RSTHGNKKPR RSSGRRESFG ALPQKRTKRK GRGGRESAPL MGKDKICSSH
210 220 230 240 250
SLPLSRTRPN LWVLEEKGNL LPNGALACSL QRRESCPPDI PKTPDTDLGF
260 270 280 290 300
GSFETAFKDT GLGREVLPPD CSSTEAGGDG IRRPPSGLEH QQTGLSESHQ
310 320 330 340 350
DPEKHPEAEK DEMEKPAKRT CKQKPVSKVV AKVQDLSSQV QRVVKTHSKG
360 370 380 390 400
KETIAIRPAA HAEFVPKADL LTLPGAEAGA HGSRRQGKER QGDRSSQSPA
410 420 430 440 450
GETASISSVS ASAEGAVNKV PLKVIESEKL DEAPEGKRLG FPVHTSVPHT
460 470 480 490 500
RPETRNKRRA GLPLGGHKSL FLDLPHKVGP DSSQPRGDKK KPSPPAPAAL
510 520 530 540 550
GKVFNNSASQ SSTHKQTSPV PSPLSPRLPS PQQHHRILRL PALPGEREAA
560 570 580 590 600
LNDSPCRKSR VFSGCVSADT LEPPSSAKVT ETKGASPAFL RAGQPRLVPG
610 620 630 640 650
ETLEKSLGPG KTTAEPQHQS PPGISSEGFP WDGFNEQTPK DLPNRDGGAW
660 670 680 690 700
VLGYRAGPAC PFLLHEEREK SNRSELYLDL HPDHSLTEQD DRTPGRLQAV
710 720 730 740 750
WPPPKTKDTE EKVGLKYTEA EYQAAILHLK REHKEEIENL QAQFELRAFH
760 770 780 790 800
IRGEHAMITA RLEETIENLK HELEHRWRGG CEERKDVCIS TDDDCPPKTF
810 820 830 840 850
RNVCVQTDRE TFLKPCESES KTTRSNQLVP KKLNISSLSQ LSPPNDHKDI
860 870 880 890 900
HAALQPMEGM ASNQQKALPP PPASIPPPPP LPSGLGSLSP APPMPPVSAG
910 920 930 940 950
PPLPPPPPPP PPLPPPSSAG PPPPPPPPPL PNSPAPPNPG GPPPAPPPPG
960 970 980 990 1000
LAPPPPPGLF FGLGSSSSQC PRKPAIEPSC PMKPLYWTRI QISDRSQNAT
1010 1020 1030 1040 1050
PTLWDSLEEP DIRDPSEFEY LFSKDTTQQK KKPLSETYEK KNKVKKIIKL
1060 1070 1080 1090 1100
LDGKRSQTVG ILISSLHLEM KDIQQAIFNV DDSVVDLETL AALYENRAQE
1110 1120 1130 1140 1150
DELVKIRKYY ETSKEEELKL LDKPEQFLHE LAQIPNFAER AQCIIFRSVF
1160 1170 1180 1190 1200
SEGITSLHRK VEIITRASKD LLHVKSVKDI LALILAFGNY MNGGNRTRGQ
1210 1220 1230 1240 1250
ADGYSLEILP KLKDVKSRDN GINLVDYVVK YYLRYYDQEA GTEKSVFPLP
1260 1270 1280 1290 1300
EPQDFFLASQ VKFEDLIKDL RKLKRQLEAS EKQMVVVCKE SPKEYLQPFK
1310 1320 1330 1340 1350
DKLEEFFQKA KKEHKMEESH LENAQKSFET TVRYFGMKPK SGEKEITPSY
1360 1370 1380 1390 1400
VFMVWYEFCS DFKTIWKRES KNISKERLKM AQESVSKLTS EKKVETKKIN
1410
PTASLKERLR QKEASVTTN
Length:1,419
Mass (Da):157,578
Last modified:April 5, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6ED2783FC8151A43
GO
Isoform 2 (identifier: Q68DA7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     623-662: GISSEGFPWD...GYRAGPACPF → AFHWDLQQHF...AGKGKESRSG
     663-1419: Missing.

Note: No experimental confirmation available.
Show »
Length:662
Mass (Da):71,892
Checksum:iC119E228B5F717DE
GO
Isoform 3 (identifier: Q68DA7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-680: Missing.
     681-681: H → MENVDNSLDG...PADGPSDSKS
     721-726: EYQAAI → GNVKGS
     727-1419: Missing.

Show »
Length:503
Mass (Da):53,619
Checksum:i0636873ED8470DF0
GO
Isoform 5 (identifier: Q68DA7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-680: Missing.
     681-681: H → MENVDNSLDG...PADGPSDSKS

Show »
Length:1,196
Mass (Da):132,156
Checksum:i29D19AC2C4245CD9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YM30H0YM30_HUMAN
Formin-1
FMN1
1,321Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YLM7H0YLM7_HUMAN
Formin-1
FMN1
181Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YL93H0YL93_HUMAN
Formin-1
FMN1
114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YMP0H0YMP0_HUMAN
Formin-1
FMN1
58Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti57S → A in CAH18313 (PubMed:17974005).Curated1
Sequence conflicti221L → P in CAH18313 (PubMed:17974005).Curated1
Isoform 3 (identifier: Q68DA7-3)
Sequence conflicti171G → V in AAI03693 (PubMed:15489334).Curated1
Sequence conflicti171G → V in AAI07594 (PubMed:15489334).Curated1
Sequence conflicti239G → E in AAI07594 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034630686L → P2 PublicationsCorresponds to variant dbSNP:rs2306277Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0272081 – 680Missing in isoform 3 and isoform 5. 1 PublicationAdd BLAST680
Alternative sequenceiVSP_027209623 – 662GISSE…PACPF → AFHWDLQQHFQEPVIRTVSI SCASNLIKEEAGKGKESRSG in isoform 2. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_027210663 – 1419Missing in isoform 2. 1 PublicationAdd BLAST757
Alternative sequenceiVSP_027211681H → MENVDNSLDGSDVSEPAKPE AGLEVAQSILSKFSMKSLFG FTSKLESVNPEEEDAVLKAF HSLDVNPTSQQDDSSNGLDP QEAGSRVSPDLGNDEKIASV ETESEGSQRKEAGTSLLAQE LLPLSTLKGTKDDVICVRGT LVHTTSDSDSDDGGQEPEEG SSTNGPKSPSGVLSEPSQES KENPGGFRENTVTGEMNGAE LCAEDPQRIPPEMSSKLEAG NGGLQTERRPSQDQVGEEGS QDLPAVTNQNSSVGITESAS SKKEVSGEKSFQLPAFFSGL RVLKKGATAEGGETITEIKP KDGDLALLKLTQPVQKSLVQ AGLQTVKSEKKATDPKATPT LLEQLSLLLNIDMPKTEPKG ADPESPRREEMGCNADQESQ SGPGVPQTQGGEVKPKSPET ALEAFKALFIRPPRKGTTAD TSELEALKRKMRHEKESLRA VFERSNSKPADGPSDSKS in isoform 3 and isoform 5. 1 Publication1
Alternative sequenceiVSP_027212721 – 726EYQAAI → GNVKGS in isoform 3. 1 Publication6
Alternative sequenceiVSP_027213727 – 1419Missing in isoform 3. 1 PublicationAdd BLAST693

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
CR749487 mRNA Translation: CAH18313.1
AC090098 Genomic DNA No translation available.
AC090877 Genomic DNA No translation available.
AC090982 Genomic DNA No translation available.
AC018515 Genomic DNA No translation available.
AC019278 Genomic DNA No translation available.
BC103692 mRNA Translation: AAI03693.1
BC107593 mRNA Translation: AAI07594.1
AK127078 mRNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS45209.1 [Q68DA7-5]
CCDS61581.1 [Q68DA7-1]
CCDS61582.1 [Q68DA7-2]

NCBI Reference Sequences

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RefSeqi
NP_001096654.1, NM_001103184.3 [Q68DA7-5]
NP_001264242.1, NM_001277313.1 [Q68DA7-1]
NP_001264243.1, NM_001277314.1 [Q68DA7-2]
XP_011519806.1, XM_011521504.2 [Q68DA7-1]
XP_016877619.1, XM_017022130.1 [Q68DA7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000320930; ENSP00000325166; ENSG00000248905 [Q68DA7-2]
ENST00000334528; ENSP00000333950; ENSG00000248905 [Q68DA7-5]
ENST00000558197; ENSP00000452984; ENSG00000248905 [Q68DA7-3]
ENST00000559047; ENSP00000454047; ENSG00000248905 [Q68DA7-1]
ENST00000616417; ENSP00000479134; ENSG00000248905 [Q68DA7-1]
ENST00000631469; ENSP00000488866; ENSG00000282513 [Q68DA7-3]
ENST00000631756; ENSP00000488300; ENSG00000282513 [Q68DA7-1]
ENST00000631811; ENSP00000488198; ENSG00000282513 [Q68DA7-5]
ENST00000632024; ENSP00000488532; ENSG00000282513 [Q68DA7-1]
ENST00000633316; ENSP00000487643; ENSG00000282513 [Q68DA7-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
342184

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:342184

UCSC genome browser

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UCSCi
uc001zhf.6 human [Q68DA7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR749487 mRNA Translation: CAH18313.1
AC090098 Genomic DNA No translation available.
AC090877 Genomic DNA No translation available.
AC090982 Genomic DNA No translation available.
AC018515 Genomic DNA No translation available.
AC019278 Genomic DNA No translation available.
BC103692 mRNA Translation: AAI03693.1
BC107593 mRNA Translation: AAI07594.1
AK127078 mRNA No translation available.
CCDSiCCDS45209.1 [Q68DA7-5]
CCDS61581.1 [Q68DA7-1]
CCDS61582.1 [Q68DA7-2]
RefSeqiNP_001096654.1, NM_001103184.3 [Q68DA7-5]
NP_001264242.1, NM_001277313.1 [Q68DA7-1]
NP_001264243.1, NM_001277314.1 [Q68DA7-2]
XP_011519806.1, XM_011521504.2 [Q68DA7-1]
XP_016877619.1, XM_017022130.1 [Q68DA7-1]

3D structure databases

SMRiQ68DA7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi131167, 7 interactors
ELMiQ68DA7
IntActiQ68DA7, 5 interactors
STRINGi9606.ENSP00000479134

PTM databases

iPTMnetiQ68DA7
PhosphoSitePlusiQ68DA7

Polymorphism and mutation databases

BioMutaiFMN1
DMDMi327478585

Proteomic databases

jPOSTiQ68DA7
MassIVEiQ68DA7
MaxQBiQ68DA7
PaxDbiQ68DA7
PeptideAtlasiQ68DA7
PRIDEiQ68DA7
ProteomicsDBi66065 [Q68DA7-1]
66066 [Q68DA7-2]
66067 [Q68DA7-3]
66068 [Q68DA7-5]

Genome annotation databases

EnsembliENST00000320930; ENSP00000325166; ENSG00000248905 [Q68DA7-2]
ENST00000334528; ENSP00000333950; ENSG00000248905 [Q68DA7-5]
ENST00000558197; ENSP00000452984; ENSG00000248905 [Q68DA7-3]
ENST00000559047; ENSP00000454047; ENSG00000248905 [Q68DA7-1]
ENST00000616417; ENSP00000479134; ENSG00000248905 [Q68DA7-1]
ENST00000631469; ENSP00000488866; ENSG00000282513 [Q68DA7-3]
ENST00000631756; ENSP00000488300; ENSG00000282513 [Q68DA7-1]
ENST00000631811; ENSP00000488198; ENSG00000282513 [Q68DA7-5]
ENST00000632024; ENSP00000488532; ENSG00000282513 [Q68DA7-1]
ENST00000633316; ENSP00000487643; ENSG00000282513 [Q68DA7-2]
GeneIDi342184
KEGGihsa:342184
UCSCiuc001zhf.6 human [Q68DA7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
342184
DisGeNETi342184

GeneCards: human genes, protein and diseases

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GeneCardsi
FMN1
HGNCiHGNC:3768 FMN1
HPAiHPA005465
HPA046786
MIMi136535 gene
neXtProtiNX_Q68DA7
OpenTargetsiENSG00000248905

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1922 Eukaryota
ENOG411149J LUCA
GeneTreeiENSGT00940000154289
HOGENOMiHOG000112617
InParanoidiQ68DA7
KOiK10367
OMAiGFNEQTP
OrthoDBi249504at2759
PhylomeDBiQ68DA7
TreeFamiTF326072

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
FMN1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
342184
PharosiQ68DA7

Protein Ontology

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PROi
PR:Q68DA7

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000248905 Expressed in 117 organ(s), highest expression level in kidney
ExpressionAtlasiQ68DA7 baseline and differential
GenevisibleiQ68DA7 HS

Family and domain databases

Gene3Di1.20.58.2220, 1 hit
InterProiView protein in InterPro
IPR015425 FH2_Formin
IPR042201 FH2_Formin_sf
IPR001265 Formin_Cappuccino_subfam
PfamiView protein in Pfam
PF02181 FH2, 1 hit
PRINTSiPR00828 FORMIN
SMARTiView protein in SMART
SM00498 FH2, 1 hit
PROSITEiView protein in PROSITE
PS51444 FH2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFMN1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q68DA7
Secondary accession number(s): Q3B7I6, Q3ZAR4, Q6ZSY1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: April 5, 2011
Last modified: October 16, 2019
This is version 122 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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