Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 152 (31 Jul 2019)
Sequence version 1 (01 Mar 2002)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

ATR-interacting protein

Gene

ATRIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein.1 Publication

Caution

The gene for this protein is either identical to or adjacent to that of TREX1. Some of the mRNAs that encode ATRIP also encode TREX1 in another reading frame.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA damage, DNA repair

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-176187 Activation of ATR in response to replication stress
R-HSA-5685938 HDR through Single Strand Annealing (SSA)
R-HSA-5693607 Processing of DNA double-strand break ends
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-HSA-6783310 Fanconi Anemia Pathway
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-69473 G2/M DNA damage checkpoint

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q8WXE1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATR-interacting protein
Alternative name(s):
ATM and Rad3-related-interacting protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATRIP
Synonyms:AGS1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:33499 ATRIP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606605 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8WXE1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi769 – 770EE → AA: Abolishes interaction with ATR and its recruitment to sites of DNA damage. 1 Publication2
Mutagenesisi774 – 775DD → AA: Abolishes interaction with ATR and its recruitment to sites of DNA damage. 1 Publication2

Organism-specific databases

DisGeNET

More...
DisGeNETi
84126

MalaCards human disease database

More...
MalaCardsi
ATRIP

Open Targets

More...
OpenTargetsi
ENSG00000164053

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
808 Seckel syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162377290

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4106138

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ATRIP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
48428109

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000647401 – 791ATR-interacting proteinAdd BLAST791

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by ATR.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-3216
CPTAC-3217
CPTAC-914
CPTAC-915

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8WXE1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8WXE1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8WXE1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8WXE1

PeptideAtlas

More...
PeptideAtlasi
Q8WXE1

PRoteomics IDEntifications database

More...
PRIDEi
Q8WXE1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
6227
75018 [Q8WXE1-1]
75019 [Q8WXE1-2]
75020 [Q8WXE1-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8WXE1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8WXE1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000164053 Expressed in 91 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8WXE1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8WXE1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB033109
HPA047590

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ATR (By similarity). Heterodimer with ATR. The heterodimer binds the RPA complex and is then recruited to single-stranded DNA.

Interacts with CEP164 (via N-terminus).

Interacts with CINP.

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
313463, 60 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-3622 ATR-ATRIP DNA damage-sensing kinase complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q8WXE1

Database of interacting proteins

More...
DIPi
DIP-46495N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q8WXE1

Protein interaction database and analysis system

More...
IntActi
Q8WXE1, 29 interactors

Molecular INTeraction database

More...
MINTi
Q8WXE1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000323099

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1791
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8WXE1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni118 – 156Interaction with CINP1 PublicationAdd BLAST39

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili108 – 217Sequence analysisAdd BLAST110

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi769 – 776EEXXXDL motif8

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The EEXXXDDL motif is required for the interaction with catalytic subunit PRKDC and its recruitment to sites of DNA damage.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ATRIP family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHIV Eukaryota
ENOG41107QS LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000012850

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000273897

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8WXE1

KEGG Orthology (KO)

More...
KOi
K10905

Identification of Orthologs from Complete Genome Data

More...
OMAi
PSFPTKE

Database of Orthologous Groups

More...
OrthoDBi
1386217at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8WXE1

TreeFam database of animal gene trees

More...
TreeFami
TF324417

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033349 ATRIP

The PANTHER Classification System

More...
PANTHERi
PTHR28594 PTHR28594, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8WXE1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGTSAPGSK RRSEPPAPRP GPPPGTGHPP SKRARGFSAA AAPDPDDPFG
60 70 80 90 100
AHGDFTADDL EELDTLASQA LSQCPAAARD VSSDHKVHRL LDGMSKNPSG
110 120 130 140 150
KNRETVPIKD NFELEVLQAQ YKELKEKMKV MEEEVLIKNG EIKILRDSLH
160 170 180 190 200
QTESVLEEQR RSHFLLEQEK TQALSDKEKE FSKKLQSLQS ELQFKDAEMN
210 220 230 240 250
ELRTKLQTSE RANKLAAPSV SHVSPRKNPS VVIKPEACSP QFGKTSFPTK
260 270 280 290 300
ESFSANMSLP HPCQTESGYK PLVGREDSKP HSLRGDSIKQ EEAQKSFVDS
310 320 330 340 350
WRQRSNTQGS ILINLLLKQP LIPGSSLSLC HLLSSSSESP AGTPLQPPGF
360 370 380 390 400
GSTLAGMSGL RTTGSYDGSF SLSALREAQN LAFTGLNLVA RNECSRDGDP
410 420 430 440 450
AEGGRRAFPL CQLPGAVHFL PLVQFFIGLH CQALQDLAAA KRSGAPGDSP
460 470 480 490 500
THSSCVSSGV ETNPEDSVCI LEGFSVTALS ILQHLVCHSG AVVSLLLSGV
510 520 530 540 550
GADSAAGEGN RSLVHRLSDG DMTSALRGVA DDQGQHPLLK MLLHLLAFSS
560 570 580 590 600
AATGHLQASV LTQCLKVLVK LAENTSCDFL PRFQCVFQVL PKCLSPETPL
610 620 630 640 650
PSVLLAVELL SLLADHDQLA PQLCSHSEGC LLLLLYMYIT SRPDRVALET
660 670 680 690 700
QWLQLEQEVV WLLAKLGVQS PLPPVTGSNC QCNVEVVRAL TVMLHRQWLT
710 720 730 740 750
VRRAGGPPRT DQQRRTVRCL RDTVLLLHGL SQKDKLFMMH CVEVLHQFDQ
760 770 780 790
VMPGVSMLIR GLPDVTDCEE AALDDLCAAE TDVEDPEVEC G
Length:791
Mass (Da):85,838
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i58981602F7961756
GO
Isoform 2 (identifier: Q8WXE1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     661-687: Missing.

Show »
Length:764
Mass (Da):83,003
Checksum:i94E7E31A6BCAAC1D
GO
Isoform 3 (identifier: Q8WXE1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-93: Missing.

Note: No experimental confirmation available.
Show »
Length:698
Mass (Da):76,336
Checksum:i417F5811408F2799
GO
Isoform 4 (identifier: Q8WXE1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-127: Missing.

Show »
Length:664
Mass (Da):72,362
Checksum:i460E7E097BCA1C30
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RRM7A0A0U1RRM7_HUMAN
ATR-interacting protein
ATRIP
196Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RQW3A0A0U1RQW3_HUMAN
ATR-interacting protein
ATRIP TREX1, hCG_1997849
464Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RQR9A0A0U1RQR9_HUMAN
ATR-interacting protein
ATRIP
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RQJ8A0A0U1RQJ8_HUMAN
ATR-interacting protein
ATRIP
604Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PQ89A0A1W2PQ89_HUMAN
ATR-interacting protein
ATRIP
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14029 differs from that shown. Reason: Frameshift at position 650.Curated
The sequence BAB14029 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAF84257 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti280P → L in AAH14153 (PubMed:15489334).Curated1
Sequence conflicti343T → A in BAF84257 (PubMed:14702039).Curated1
Sequence conflicti492V → I in BAF84257 (PubMed:14702039).Curated1
Sequence conflicti647A → T in BAG62254 (PubMed:14702039).Curated1
Sequence conflicti683N → D in BAF84257 (PubMed:14702039).Curated1
Sequence conflicti687V → I in AAH30597 (PubMed:15489334).Curated1
Sequence conflicti712Q → K in BAF84257 (PubMed:14702039).Curated1
Sequence conflicti777C → G in BAF84257 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050683125K → Q. Corresponds to variant dbSNP:rs11925638Ensembl.1
Natural variantiVAR_050684240P → L. Corresponds to variant dbSNP:rs35240314Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0470111 – 127Missing in isoform 4. 1 PublicationAdd BLAST127
Alternative sequenceiVSP_0105011 – 93Missing in isoform 3. 1 PublicationAdd BLAST93
Alternative sequenceiVSP_010504661 – 687Missing in isoform 2. 2 PublicationsAdd BLAST27

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF451323 mRNA Translation: AAL38042.1
AK022405 mRNA Translation: BAB14029.1 Sequence problems.
AK291568 mRNA Translation: BAF84257.1 Different initiation.
AK291829 mRNA Translation: BAF84518.1
AK315075 mRNA Translation: BAG37544.1
AK300548 mRNA Translation: BAG62254.1
AC104448 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64876.1
CH471055 Genomic DNA Translation: EAW64878.1
BC014153 mRNA Translation: AAH14153.2
BC020563 mRNA Translation: AAH20563.1
BC030597 mRNA Translation: AAH30597.1
AL832917 mRNA Translation: CAH10621.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2767.1 [Q8WXE1-2]
CCDS2768.1 [Q8WXE1-1]
CCDS59449.1 [Q8WXE1-3]
CCDS59450.1 [Q8WXE1-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001257951.1, NM_001271022.1 [Q8WXE1-5]
NP_001257952.1, NM_001271023.1 [Q8WXE1-3]
NP_115542.2, NM_032166.3 [Q8WXE1-2]
NP_569055.1, NM_130384.2 [Q8WXE1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000320211; ENSP00000323099; ENSG00000164053 [Q8WXE1-1]
ENST00000346691; ENSP00000302338; ENSG00000164053 [Q8WXE1-2]
ENST00000357105; ENSP00000349620; ENSG00000164053 [Q8WXE1-5]
ENST00000412052; ENSP00000400930; ENSG00000164053 [Q8WXE1-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84126

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84126

UCSC genome browser

More...
UCSCi
uc003ctf.3 human [Q8WXE1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF451323 mRNA Translation: AAL38042.1
AK022405 mRNA Translation: BAB14029.1 Sequence problems.
AK291568 mRNA Translation: BAF84257.1 Different initiation.
AK291829 mRNA Translation: BAF84518.1
AK315075 mRNA Translation: BAG37544.1
AK300548 mRNA Translation: BAG62254.1
AC104448 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64876.1
CH471055 Genomic DNA Translation: EAW64878.1
BC014153 mRNA Translation: AAH14153.2
BC020563 mRNA Translation: AAH20563.1
BC030597 mRNA Translation: AAH30597.1
AL832917 mRNA Translation: CAH10621.1
CCDSiCCDS2767.1 [Q8WXE1-2]
CCDS2768.1 [Q8WXE1-1]
CCDS59449.1 [Q8WXE1-3]
CCDS59450.1 [Q8WXE1-5]
RefSeqiNP_001257951.1, NM_001271022.1 [Q8WXE1-5]
NP_001257952.1, NM_001271023.1 [Q8WXE1-3]
NP_115542.2, NM_032166.3 [Q8WXE1-2]
NP_569055.1, NM_130384.2 [Q8WXE1-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4IGKX-ray1.75C/D237-243[»]
4NB3X-ray1.35C/D54-67[»]
5YZ0electron microscopy4.70C/D1-791[»]
SMRiQ8WXE1
ModBaseiSearch...

Protein-protein interaction databases

BioGridi313463, 60 interactors
ComplexPortaliCPX-3622 ATR-ATRIP DNA damage-sensing kinase complex
CORUMiQ8WXE1
DIPiDIP-46495N
ELMiQ8WXE1
IntActiQ8WXE1, 29 interactors
MINTiQ8WXE1
STRINGi9606.ENSP00000323099

Chemistry databases

ChEMBLiCHEMBL4106138

PTM databases

iPTMnetiQ8WXE1
PhosphoSitePlusiQ8WXE1

Polymorphism and mutation databases

BioMutaiATRIP
DMDMi48428109

Proteomic databases

CPTACiCPTAC-3216
CPTAC-3217
CPTAC-914
CPTAC-915
EPDiQ8WXE1
jPOSTiQ8WXE1
MaxQBiQ8WXE1
PaxDbiQ8WXE1
PeptideAtlasiQ8WXE1
PRIDEiQ8WXE1
ProteomicsDBi6227
75018 [Q8WXE1-1]
75019 [Q8WXE1-2]
75020 [Q8WXE1-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
84126
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320211; ENSP00000323099; ENSG00000164053 [Q8WXE1-1]
ENST00000346691; ENSP00000302338; ENSG00000164053 [Q8WXE1-2]
ENST00000357105; ENSP00000349620; ENSG00000164053 [Q8WXE1-5]
ENST00000412052; ENSP00000400930; ENSG00000164053 [Q8WXE1-3]
GeneIDi84126
KEGGihsa:84126
UCSCiuc003ctf.3 human [Q8WXE1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84126
DisGeNETi84126

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ATRIP
HGNCiHGNC:33499 ATRIP
HPAiCAB033109
HPA047590
MalaCardsiATRIP
MIMi606605 gene
neXtProtiNX_Q8WXE1
OpenTargetsiENSG00000164053
Orphaneti808 Seckel syndrome
PharmGKBiPA162377290

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IHIV Eukaryota
ENOG41107QS LUCA
GeneTreeiENSGT00390000012850
HOGENOMiHOG000273897
InParanoidiQ8WXE1
KOiK10905
OMAiPSFPTKE
OrthoDBi1386217at2759
PhylomeDBiQ8WXE1
TreeFamiTF324417

Enzyme and pathway databases

ReactomeiR-HSA-176187 Activation of ATR in response to replication stress
R-HSA-5685938 HDR through Single Strand Annealing (SSA)
R-HSA-5693607 Processing of DNA double-strand break ends
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-HSA-6783310 Fanconi Anemia Pathway
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-69473 G2/M DNA damage checkpoint
SIGNORiQ8WXE1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ATRIP human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84126

Protein Ontology

More...
PROi
PR:Q8WXE1

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000164053 Expressed in 91 organ(s), highest expression level in testis
ExpressionAtlasiQ8WXE1 baseline and differential
GenevisibleiQ8WXE1 HS

Family and domain databases

InterProiView protein in InterPro
IPR033349 ATRIP
PANTHERiPTHR28594 PTHR28594, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATRIP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8WXE1
Secondary accession number(s): A8K6A3
, A8K714, B2RCE7, B4DU92, B5MEB7, Q69YK9, Q8NHQ2, Q8WUG7, Q96CL3, Q9HA30
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: March 1, 2002
Last modified: July 31, 2019
This is version 152 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again