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Entry version 176 (18 Sep 2019)
Sequence version 2 (10 Feb 2009)
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Protein

Protein TFG

Gene

TFG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed:23479643, PubMed:27813252). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:21478858).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processER-Golgi transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-204005 COPII-mediated vesicle transport

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q92734

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q92734

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...
MoonDBi
Q92734 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein TFG
Alternative name(s):
TRK-fused gene protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TFG
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:11758 TFG

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602498 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q92734

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving TFG is found in papillary thyroid carcinomas (PTCs). Translocation t(1;3)(q21;q11) with NTRK1. The TFG sequence is fused to the 3'-end of NTRK1 generating the TRKT3 (TRK-T3) fusion transcript.1 Publication
Neuropathy, hereditary motor and sensory, Okinawa type (HMSNO)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA neurodegenerative disorder characterized by young adult onset of proximal muscle weakness and atrophy, muscle cramps, and fasciculations, with later onset of distal sensory impairment. The disorder is slowly progressive and clinically resembles amyotrophic lateral sclerosis.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_068917285P → L in HMSNO; does not affect interaction with PDCD6. 2 PublicationsCorresponds to variant dbSNP:rs207482230EnsemblClinVar.1
Spastic paraplegia 57, autosomal recessive (SPG57)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA complicated form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. Complicated forms are recognized by additional variable features including spastic quadriparesis, seizures, dementia, amyotrophy, extrapyramidal disturbance, cerebral or cerebellar atrophy, optic atrophy, and peripheral neuropathy, as well as by extra neurological manifestations.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070986106R → C in SPG57; defective self-assembly into an oligomeric complex; impaired interaction with PDCD6; causes mitochondrial fragmentation. 3 PublicationsCorresponds to variant dbSNP:rs587777175EnsemblClinVar.1
Natural variantiVAR_078075106R → H in SPG57; causes mitochondrial fragmentation. 1 PublicationCorresponds to variant dbSNP:rs376971794Ensembl.1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei193 – 194Breakpoint for translocation to form TRK-T32

Keywords - Diseasei

Disease mutation, Hereditary spastic paraplegia, Neurodegeneration, Neuropathy, Proto-oncogene

Organism-specific databases

DisGeNET

More...
DisGeNETi
10342

MalaCards human disease database

More...
MalaCardsi
TFG
MIMi604484 phenotype
615658 phenotype

Open Targets

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OpenTargetsi
ENSG00000114354

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
435819 Autosomal dominant Charcot-Marie-Tooth disease type 2 due to TFG mutation
431329 Autosomal recessive spastic paraplegia type 57
146 Differentiated thyroid carcinoma
209916 Extraskeletal myxoid chondrosarcoma
90117 Hereditary motor and sensory neuropathy, Okinawa type

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA36473

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TFG

Domain mapping of disease mutations (DMDM)

More...
DMDMi
223634676

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000725001 – 400Protein TFGAdd BLAST400

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei50PhosphoserineCombined sources1
Modified residuei197PhosphoserineCombined sources1
Modified residuei385Omega-N-methylarginineCombined sources1
Modified residuei400Omega-N-methylarginineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q92734

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q92734

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q92734

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q92734

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q92734

PeptideAtlas

More...
PeptideAtlasi
Q92734

PRoteomics IDEntifications database

More...
PRIDEi
Q92734

ProteomicsDB human proteome resource

More...
ProteomicsDBi
34050
75430 [Q92734-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q92734

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q92734

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q92734

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000114354 Expressed in 221 organ(s), highest expression level in secondary oocyte

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q92734 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q92734 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA019473
HPA052206

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Self-associates to form an oligomeric complex (PubMed:23479643).

Interacts with PDCD6; promoting localization and polymerization of TFG at endoplasmic reticulum exit site (PubMed:27813252).

Interacts with SEC16B (PubMed:21478858).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115624, 137 interactors

Protein interaction database and analysis system

More...
IntActi
Q92734, 150 interactors

Molecular INTeraction database

More...
MINTi
Q92734

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000240851

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q92734

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini10 – 91PB1PROSITE-ProRule annotationAdd BLAST82

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili97 – 124Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IH8P Eukaryota
ENOG410Z8FQ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00510000047809

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000132915

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q92734

KEGG Orthology (KO)

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KOi
K09292

Identification of Orthologs from Complete Genome Data

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OMAi
QGAQQYP

Database of Orthologous Groups

More...
OrthoDBi
1095345at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q92734

TreeFam database of animal gene trees

More...
TreeFami
TF318743

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06401 PB1_TFG, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000270 PB1_dom
IPR034857 PB1_TFG
IPR033512 TFG

The PANTHER Classification System

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PANTHERi
PTHR15335 PTHR15335, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00564 PB1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00666 PB1, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51745 PB1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q92734-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNGQLDLSGK LIIKAQLGED IRRIPIHNED ITYDELVLMM QRVFRGKLLS
60 70 80 90 100
NDEVTIKYKD EDGDLITIFD SSDLSFAIQC SRILKLTLFV NGQPRPLESS
110 120 130 140 150
QVKYLRRELI ELRNKVNRLL DSLEPPGEPG PSTNIPENDT VDGREEKSAS
160 170 180 190 200
DSSGKQSTQV MAASMSAFDP LKNQDEINKN VMSAFGLTDD QVSGPPSAPA
210 220 230 240 250
EDRSGTPDSI ASSSSAAHPP GVQPQQPPYT GAQTQAGQIE GQMYQQYQQQ
260 270 280 290 300
AGYGAQQPQA PPQQPQQYGI QYSASYSQQT GPQQPQQFQG YGQQPTSQAP
310 320 330 340 350
APAFSGQPQQ LPAQPPQQYQ ASNYPAQTYT AQTSQPTNYT VAPASQPGMA
360 370 380 390 400
PSQPGAYQPR PGFTSLPGST MTPPPSGPNP YARNRPPFGQ GYTQPGPGYR
Length:400
Mass (Da):43,448
Last modified:February 10, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD8A559D0F7314D1F
GO
Isoform 2 (identifier: Q92734-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     237-240: Missing.

Note: No experimental confirmation available.
Show »
Length:396
Mass (Da):43,020
Checksum:iE4FF3B134949F61C
GO
Isoform 3 (identifier: Q92734-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     274-284: ASYSQQTGPQQ → GFQSMERFHCK
     285-400: Missing.

Show »
Length:284
Mass (Da):31,349
Checksum:iCCE52A4FFE1C9208
GO
Isoform 4 (identifier: Q92734-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     237-240: Missing.
     274-284: ASYSQQTGPQQ → GFQSMERFHCK
     285-400: Missing.

Show »
Length:280
Mass (Da):30,921
Checksum:i15A1AE17A24AD3C9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JUE0C9JUE0_HUMAN
Protein TFG
TFG
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JTY3C9JTY3_HUMAN
Protein TFG
TFG
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JJP5C9JJP5_HUMAN
Protein TFG
TFG
181Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti13I → V in CAA69264 (PubMed:9169129).Curated1
Sequence conflicti13I → V in CAA59936 (PubMed:7565764).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070986106R → C in SPG57; defective self-assembly into an oligomeric complex; impaired interaction with PDCD6; causes mitochondrial fragmentation. 3 PublicationsCorresponds to variant dbSNP:rs587777175EnsemblClinVar.1
Natural variantiVAR_078075106R → H in SPG57; causes mitochondrial fragmentation. 1 PublicationCorresponds to variant dbSNP:rs376971794Ensembl.1
Natural variantiVAR_035668149A → S in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_054322211A → V. Corresponds to variant dbSNP:rs430945Ensembl.1
Natural variantiVAR_068917285P → L in HMSNO; does not affect interaction with PDCD6. 2 PublicationsCorresponds to variant dbSNP:rs207482230EnsemblClinVar.1
Natural variantiVAR_054323364T → P. Corresponds to variant dbSNP:rs6772054EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_047131237 – 240Missing in isoform 2 and isoform 4. Curated4
Alternative sequenceiVSP_057414274 – 284ASYSQQTGPQQ → GFQSMERFHCK in isoform 3 and isoform 4. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_057415285 – 400Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST116

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y07968 mRNA Translation: CAA69264.1
AB731569 mRNA Translation: BAM48926.1
AB731570 mRNA Translation: BAM48927.1
AK093456 mRNA Translation: BAG52721.1
BT007428 mRNA Translation: AAP36096.1
CR456781 mRNA Translation: CAG33062.1
AC068763 Genomic DNA No translation available.
KF457659 Genomic DNA No translation available.
KF457666 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79813.1
CH471052 Genomic DNA Translation: EAW79814.1
CH471052 Genomic DNA Translation: EAW79815.1
CH471052 Genomic DNA Translation: EAW79816.1
CH471052 Genomic DNA Translation: EAW79817.1
BC001483 mRNA Translation: AAH01483.1
BC009241 mRNA Translation: AAH09241.1
BC023599 mRNA Translation: AAH23599.1
X85960 mRNA Translation: CAA59936.1 Different termination.

The Consensus CDS (CCDS) project

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CCDSi
CCDS2939.1 [Q92734-1]
CCDS56266.1 [Q92734-2]

NCBI Reference Sequences

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RefSeqi
NP_001007566.1, NM_001007565.2 [Q92734-1]
NP_001182407.1, NM_001195478.1 [Q92734-1]
NP_001182408.1, NM_001195479.1 [Q92734-2]
NP_006061.2, NM_006070.5 [Q92734-1]
XP_005247123.1, XM_005247066.1 [Q92734-2]
XP_006713535.1, XM_006713472.1 [Q92734-1]
XP_006713536.1, XM_006713473.1
XP_011510636.1, XM_011512334.1 [Q92734-1]
XP_016861016.1, XM_017005527.1 [Q92734-2]
XP_016861017.1, XM_017005528.1
XP_016861018.1, XM_017005529.1
XP_016861019.1, XM_017005530.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000240851; ENSP00000240851; ENSG00000114354 [Q92734-1]
ENST00000418917; ENSP00000397182; ENSG00000114354 [Q92734-2]
ENST00000476228; ENSP00000417952; ENSG00000114354 [Q92734-2]
ENST00000490574; ENSP00000419960; ENSG00000114354 [Q92734-1]
ENST00000615993; ENSP00000479269; ENSG00000114354 [Q92734-3]
ENST00000620299; ENSP00000479981; ENSG00000114354 [Q92734-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10342

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10342

UCSC genome browser

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UCSCi
uc003due.4 human [Q92734-1]
uc031sau.2 human

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07968 mRNA Translation: CAA69264.1
AB731569 mRNA Translation: BAM48926.1
AB731570 mRNA Translation: BAM48927.1
AK093456 mRNA Translation: BAG52721.1
BT007428 mRNA Translation: AAP36096.1
CR456781 mRNA Translation: CAG33062.1
AC068763 Genomic DNA No translation available.
KF457659 Genomic DNA No translation available.
KF457666 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79813.1
CH471052 Genomic DNA Translation: EAW79814.1
CH471052 Genomic DNA Translation: EAW79815.1
CH471052 Genomic DNA Translation: EAW79816.1
CH471052 Genomic DNA Translation: EAW79817.1
BC001483 mRNA Translation: AAH01483.1
BC009241 mRNA Translation: AAH09241.1
BC023599 mRNA Translation: AAH23599.1
X85960 mRNA Translation: CAA59936.1 Different termination.
CCDSiCCDS2939.1 [Q92734-1]
CCDS56266.1 [Q92734-2]
RefSeqiNP_001007566.1, NM_001007565.2 [Q92734-1]
NP_001182407.1, NM_001195478.1 [Q92734-1]
NP_001182408.1, NM_001195479.1 [Q92734-2]
NP_006061.2, NM_006070.5 [Q92734-1]
XP_005247123.1, XM_005247066.1 [Q92734-2]
XP_006713535.1, XM_006713472.1 [Q92734-1]
XP_006713536.1, XM_006713473.1
XP_011510636.1, XM_011512334.1 [Q92734-1]
XP_016861016.1, XM_017005527.1 [Q92734-2]
XP_016861017.1, XM_017005528.1
XP_016861018.1, XM_017005529.1
XP_016861019.1, XM_017005530.1

3D structure databases

SMRiQ92734
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115624, 137 interactors
IntActiQ92734, 150 interactors
MINTiQ92734
STRINGi9606.ENSP00000240851

Protein family/group databases

MoonDBiQ92734 Predicted

PTM databases

iPTMnetiQ92734
PhosphoSitePlusiQ92734
SwissPalmiQ92734

Polymorphism and mutation databases

BioMutaiTFG
DMDMi223634676

Proteomic databases

EPDiQ92734
jPOSTiQ92734
MassIVEiQ92734
MaxQBiQ92734
PaxDbiQ92734
PeptideAtlasiQ92734
PRIDEiQ92734
ProteomicsDBi34050
75430 [Q92734-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10342
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000240851; ENSP00000240851; ENSG00000114354 [Q92734-1]
ENST00000418917; ENSP00000397182; ENSG00000114354 [Q92734-2]
ENST00000476228; ENSP00000417952; ENSG00000114354 [Q92734-2]
ENST00000490574; ENSP00000419960; ENSG00000114354 [Q92734-1]
ENST00000615993; ENSP00000479269; ENSG00000114354 [Q92734-3]
ENST00000620299; ENSP00000479981; ENSG00000114354 [Q92734-3]
GeneIDi10342
KEGGihsa:10342
UCSCiuc003due.4 human [Q92734-1]
uc031sau.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10342
DisGeNETi10342

GeneCards: human genes, protein and diseases

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GeneCardsi
TFG
HGNCiHGNC:11758 TFG
HPAiHPA019473
HPA052206
MalaCardsiTFG
MIMi602498 gene
604484 phenotype
615658 phenotype
neXtProtiNX_Q92734
OpenTargetsiENSG00000114354
Orphaneti435819 Autosomal dominant Charcot-Marie-Tooth disease type 2 due to TFG mutation
431329 Autosomal recessive spastic paraplegia type 57
146 Differentiated thyroid carcinoma
209916 Extraskeletal myxoid chondrosarcoma
90117 Hereditary motor and sensory neuropathy, Okinawa type
PharmGKBiPA36473

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IH8P Eukaryota
ENOG410Z8FQ LUCA
GeneTreeiENSGT00510000047809
HOGENOMiHOG000132915
InParanoidiQ92734
KOiK09292
OMAiQGAQQYP
OrthoDBi1095345at2759
PhylomeDBiQ92734
TreeFamiTF318743

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII-mediated vesicle transport
SignaLinkiQ92734
SIGNORiQ92734

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TFG human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TFG_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10342

Pharos

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Pharosi
Q92734

Protein Ontology

More...
PROi
PR:Q92734

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000114354 Expressed in 221 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiQ92734 baseline and differential
GenevisibleiQ92734 HS

Family and domain databases

CDDicd06401 PB1_TFG, 1 hit
InterProiView protein in InterPro
IPR000270 PB1_dom
IPR034857 PB1_TFG
IPR033512 TFG
PANTHERiPTHR15335 PTHR15335, 1 hit
PfamiView protein in Pfam
PF00564 PB1, 1 hit
SMARTiView protein in SMART
SM00666 PB1, 1 hit
PROSITEiView protein in PROSITE
PS51745 PB1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTFG_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92734
Secondary accession number(s): D3DN49
, G5E9V1, K0J5S8, K0J6K2, Q15656, Q969I2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: February 10, 2009
Last modified: September 18, 2019
This is version 176 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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