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Entry version 142 (16 Oct 2019)
Sequence version 2 (01 Jun 2002)
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Protein

rRNA methyltransferase 3, mitochondrial

Gene

MRM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1370 (Gm1370) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mtLSU rRNA.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei356S-adenosyl-L-methionine; via carbonyl oxygenBy similarity1
Binding sitei380S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei389S-adenosyl-L-methionine; via amide nitrogenBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processrRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6793080 rRNA modification in the mitochondrion

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
rRNA methyltransferase 3, mitochondrial1 Publication (EC:2.1.1.-2 Publications)
Alternative name(s):
16S rRNA (guanosine(1370)-2'-O)-methyltransferase1 Publication
16S rRNA [Gm1370] 2'-O-methyltransferase1 Publication
RNA methyltransferase-like protein 11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MRM31 PublicationImported
Synonyms:RNMTL11 Publication
ORF Names:HC90
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18485 MRM3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612600 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9HC36

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000171861

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38341

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9HC36

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MRM3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74734265

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 40MitochondrionSequence analysisAdd BLAST40
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000031130141 – 420rRNA methyltransferase 3, mitochondrialAdd BLAST380

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9HC36

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9HC36

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9HC36

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9HC36

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9HC36

PeptideAtlas

More...
PeptideAtlasi
Q9HC36

PRoteomics IDEntifications database

More...
PRIDEi
Q9HC36

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
81632

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9HC36

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9HC36

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at same level in normal liver and hepatocarcinoma.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000171861 Expressed in 206 organ(s), highest expression level in endothelial cell

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9HC36 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9HC36 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA022534
HPA023031
HPA023292

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q136435EBI-1045440,EBI-741101

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120477, 67 interactors

Protein interaction database and analysis system

More...
IntActi
Q9HC36, 52 interactors

Molecular INTeraction database

More...
MINTi
Q9HC36

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000306080

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9HC36

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2506 Eukaryota
COG0566 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017317

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154151

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9HC36

KEGG Orthology (KO)

More...
KOi
K20095

Identification of Orthologs from Complete Genome Data

More...
OMAi
RYDKAFP

Database of Orthologous Groups

More...
OrthoDBi
1183644at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9HC36

TreeFam database of animal gene trees

More...
TreeFami
TF323420

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1330.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029028 Alpha/beta_knot_MTases
IPR029064 L30e-like
IPR001537 SpoU_MeTrfase
IPR013123 SpoU_subst-bd

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00588 SpoU_methylase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00967 SpoU_sub_bind, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55315 SSF55315, 1 hit
SSF75217 SSF75217, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9HC36-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAALVRPARF VVRPLLQVVQ AWDLDARRWV RALRRSPVKV VFPSGEVVEQ
60 70 80 90 100
KRAPGKQPRK APSEASAQEQ REKQPLEESA SRAPSTWEES GLRYDKAYPG
110 120 130 140 150
DRRLSSVMTI VKSRPFREKQ GKILLEGRRL ISDALKAGAV PKMFFFSRLE
160 170 180 190 200
YLKELPVDKL KGVSLIKVKF EDIKDWSDLV TPQGIMGIFA KPDHVKMTYP
210 220 230 240 250
KTQLQHSLPL LLICDNLRDP GNLGTILRSA AGAGCSKVLL TKGCVDAWEP
260 270 280 290 300
KVLRAGMGAH FRMPIINNLE WETVPNYLPP DTRVYVADNC GLYAQAEMSN
310 320 330 340 350
KASDHGWVCD QRVMKFHKYE EEEDVETGAS QDWLPHVEVQ SYDSDWTEAP
360 370 380 390 400
AAVVIGGETY GVSLESLQLA ESTGGKRLLI PVVPGVDSLN SAMAASILLF
410 420
EGKRQLRGRA EDLSRDRSYH
Length:420
Mass (Da):47,020
Last modified:June 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCC06C27489A89FC3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L443I3L443_HUMAN
rRNA methyltransferase 3, mitochond...
MRM3
177Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L0T6I3L0T6_HUMAN
rRNA methyltransferase 3, mitochond...
MRM3
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti247A → V in BAD96620 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0372178A → S1 PublicationCorresponds to variant dbSNP:rs2273454Ensembl.1
Natural variantiVAR_03721845G → E. Corresponds to variant dbSNP:rs2249542Ensembl.1
Natural variantiVAR_037219185I → V1 PublicationCorresponds to variant dbSNP:rs17854653Ensembl.1
Natural variantiVAR_037220326E → Q. Corresponds to variant dbSNP:rs35780267Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK001443 mRNA Translation: BAA91694.1
AK222900 mRNA Translation: BAD96620.1
AF177344 mRNA Translation: AAG17988.2
CH471108 Genomic DNA Translation: EAW90642.1
BC011550 mRNA Translation: AAH11550.1
BC050614 mRNA Translation: AAH50614.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10997.1

NCBI Reference Sequences

More...
RefSeqi
NP_001304876.1, NM_001317947.1
NP_060616.1, NM_018146.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000304478; ENSP00000306080; ENSG00000171861

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55178

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55178

UCSC genome browser

More...
UCSCi
uc002frw.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001443 mRNA Translation: BAA91694.1
AK222900 mRNA Translation: BAD96620.1
AF177344 mRNA Translation: AAG17988.2
CH471108 Genomic DNA Translation: EAW90642.1
BC011550 mRNA Translation: AAH11550.1
BC050614 mRNA Translation: AAH50614.1
CCDSiCCDS10997.1
RefSeqiNP_001304876.1, NM_001317947.1
NP_060616.1, NM_018146.3

3D structure databases

SMRiQ9HC36
ModBaseiSearch...

Protein-protein interaction databases

BioGridi120477, 67 interactors
IntActiQ9HC36, 52 interactors
MINTiQ9HC36
STRINGi9606.ENSP00000306080

PTM databases

iPTMnetiQ9HC36
PhosphoSitePlusiQ9HC36

Polymorphism and mutation databases

BioMutaiMRM3
DMDMi74734265

Proteomic databases

EPDiQ9HC36
jPOSTiQ9HC36
MassIVEiQ9HC36
MaxQBiQ9HC36
PaxDbiQ9HC36
PeptideAtlasiQ9HC36
PRIDEiQ9HC36
ProteomicsDBi81632

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
55178

Genome annotation databases

EnsembliENST00000304478; ENSP00000306080; ENSG00000171861
GeneIDi55178
KEGGihsa:55178
UCSCiuc002frw.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55178

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MRM3
HGNCiHGNC:18485 MRM3
HPAiHPA022534
HPA023031
HPA023292
MIMi612600 gene
neXtProtiNX_Q9HC36
OpenTargetsiENSG00000171861
PharmGKBiPA38341

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2506 Eukaryota
COG0566 LUCA
GeneTreeiENSGT00390000017317
HOGENOMiHOG000154151
InParanoidiQ9HC36
KOiK20095
OMAiRYDKAFP
OrthoDBi1183644at2759
PhylomeDBiQ9HC36
TreeFamiTF323420

Enzyme and pathway databases

ReactomeiR-HSA-6793080 rRNA modification in the mitochondrion

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MRM3 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
RNMTL1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55178
PharosiQ9HC36

Protein Ontology

More...
PROi
PR:Q9HC36

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000171861 Expressed in 206 organ(s), highest expression level in endothelial cell
ExpressionAtlasiQ9HC36 baseline and differential
GenevisibleiQ9HC36 HS

Family and domain databases

Gene3Di3.30.1330.30, 1 hit
InterProiView protein in InterPro
IPR029028 Alpha/beta_knot_MTases
IPR029064 L30e-like
IPR001537 SpoU_MeTrfase
IPR013123 SpoU_subst-bd
PfamiView protein in Pfam
PF00588 SpoU_methylase, 1 hit
SMARTiView protein in SMART
SM00967 SpoU_sub_bind, 1 hit
SUPFAMiSSF55315 SSF55315, 1 hit
SSF75217 SSF75217, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMRM3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HC36
Secondary accession number(s): Q53GN1
, Q86VC3, Q96F76, Q9NVQ5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: June 1, 2002
Last modified: October 16, 2019
This is version 142 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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