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Entry version 153 (08 May 2019)
Sequence version 1 (01 Oct 2000)
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Protein

Regulating synaptic membrane exocytosis protein 1

Gene

Rims1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Rab effector involved in exocytosis. May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity. Plays a role in dendrite formation by melanocytes.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri133 – 193FYVE-typePROSITE-ProRule annotationAdd BLAST61

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation, Exocytosis, Neurotransmitter transport, Transport
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-181429 Serotonin Neurotransmitter Release Cycle
R-RNO-181430 Norepinephrine Neurotransmitter Release Cycle
R-RNO-210500 Glutamate Neurotransmitter Release Cycle
R-RNO-212676 Dopamine Neurotransmitter Release Cycle
R-RNO-264642 Acetylcholine Neurotransmitter Release Cycle
R-RNO-888590 GABA synthesis, release, reuptake and degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Regulating synaptic membrane exocytosis protein 1
Alternative name(s):
Rab-3-interacting molecule 1
Short name:
RIM 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rims1
Synonyms:Rim1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
620000 Rims1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001902001 – 1615Regulating synaptic membrane exocytosis protein 1Add BLAST1615

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei514PhosphoserineCombined sources1
Modified residuei592PhosphoserineCombined sources1
Modified residuei742PhosphoserineCombined sources1
Modified residuei745PhosphoserineBy similarity1
Modified residuei895PhosphoserineBy similarity1
Modified residuei991PhosphoserineCombined sources1
Modified residuei1045PhosphoserineBy similarity1
Modified residuei1175PhosphoserineCombined sources1
Modified residuei1177PhosphothreonineCombined sources1
Modified residuei1179PhosphoserineCombined sources1
Modified residuei1231PhosphoserineCombined sources1
Modified residuei1233PhosphoserineCombined sources1
Modified residuei1234PhosphoserineCombined sources1
Modified residuei1262PhosphoserineBy similarity1
Modified residuei1263PhosphoserineBy similarity1
Modified residuei1265PhosphoserineBy similarity1
Modified residuei1339PhosphoserineCombined sources1
Modified residuei1600PhosphoserineCombined sources1
Modified residuei1603PhosphoserineCombined sources1
Modified residuei1606PhosphoserineBy similarity1
Modified residuei1615PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by BRSK1.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9JIR4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9JIR4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9JIR4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in hippocampus, brain cortex, cerebellum and olfactory bulb. Detected at lower levels in midbrain, hindbrain and spinal cord. Detected retina and in spinal cord motor neurons.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RAB3C, RAB10, RAB26 AND RAB37 (By similarity). Binds SNAP25, SYT1 and CACNA1B. Interaction with SYT1 is enhanced by calcium ions. Interaction with SNAP25 is weaker in the presence of calcium ions. Binds RAB3A, RAB3B and RAB3D that have been activated by GTP-binding. Binds UNC13A.

Interacts with TSPOAP1 and RIMBP2.

Interacts with PPFIA3 and PPFIA4.

Interacts with ERC1.

By similarity5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
250003, 1 interactor

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9JIR4

Database of interacting proteins

More...
DIPi
DIP-41432N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q9JIR4

Protein interaction database and analysis system

More...
IntActi
Q9JIR4, 8 interactors

Molecular INTeraction database

More...
MINTi
Q9JIR4

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000015454

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11615
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9JIR4

Database of comparative protein structure models

More...
ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9JIR4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 205RabBDPROSITE-ProRule annotationAdd BLAST184
Domaini619 – 705PDZPROSITE-ProRule annotationAdd BLAST87
Domaini758 – 864C2 1PROSITE-ProRule annotationAdd BLAST107
Domaini1461 – 1563C2 2PROSITE-ProRule annotationAdd BLAST103

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi422 – 455Ala-richAdd BLAST34
Compositional biasi444 – 483Pro-richAdd BLAST40
Compositional biasi1259 – 1301Ser-richAdd BLAST43

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri133 – 193FYVE-typePROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9JIR4

KEGG Orthology (KO)

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KOi
K15291

Database of Orthologous Groups

More...
OrthoDBi
109268at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9JIR4

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.150, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR041282 FYVE_2
IPR001478 PDZ
IPR036034 PDZ_sf
IPR010911 Rab_BD
IPR039032 Rim-like
IPR030630 RIM1
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD

The PANTHER Classification System

More...
PANTHERi
PTHR12157 PTHR12157, 2 hits
PTHR12157:SF19 PTHR12157:SF19, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168 C2, 2 hits
PF02318 FYVE_2, 1 hit
PF00595 PDZ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239 C2, 2 hits
SM00228 PDZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50156 SSF50156, 1 hit
SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004 C2, 2 hits
PS50106 PDZ, 1 hit
PS50916 RABBD, 1 hit
PS50178 ZF_FYVE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9JIR4-1) [UniParc]FASTAAdd to basket
Also known as: Rim1B

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSAVGPRGP RPPTVPPPMQ ELPDLSHLTE EERNIIMAVM DRQKEEEEKE
60 70 80 90 100
EAMLKCVVRD MAKPAACKTP RNAESQPHQP PLNIFRCVCV PRKPSSEEGG
110 120 130 140 150
PERDWRLHQQ FESYKEQVRK IGEEARRYQG EHKDDAPTCG ICHKTKFADG
160 170 180 190 200
CGHLCSYCRT KFCARCGGRV SLRSNNEDKV VMWVCNLCRK QQEILTKSGA
210 220 230 240 250
WFFGSGPQQP SQDGTLSDTA TGAGSEVPRE KKARLQERSR SQTPLSTAAV
260 270 280 290 300
SSQDTATPGA PLHRNKGAEP SQQALGPEQK QASRSRSEPP RERKKAPGLS
310 320 330 340 350
EQNGKGGQKS ERKRVPKSVV QPGEGIADER ERKERRETRR LEKGRSQDYS
360 370 380 390 400
DRPEKRDNGR VAEDQKQRKE EEYQTRYRSD PNLARYPVKA PPEEQQMRMH
410 420 430 440 450
ARVSRARHER RHSDVALPHT EAAAAAPAEA TAGKRAPATA RVSPPESPRA
460 470 480 490 500
RAAAAQPPTE HGPPPPRPAP GPAEPPEPRV PEPLRKQGRL DPGSAVLLRK
510 520 530 540 550
AKREKAESML RNDSLSSDQS ESVRPSPPKP HRPKRGGKRR QMSVSSSEEE
560 570 580 590 600
GVSTPEYTSC EDVELESESV SEKGDLDYYW LDPATWHSRE TSPISSHPVT
610 620 630 640 650
WQPSKEGDRL IGRVILNKRT TMPKESGALL GLKVVGGKMT DLGRLGAFIT
660 670 680 690 700
KVKKGSLADV VGHLRAGDEV LEWNGKPLPG ATNEEVYNII LESKSEPQVE
710 720 730 740 750
IIVSRPIGDI PRIPESSHPP LESSSSSFES QKMERPSISV ISPTSPGALK
760 770 780 790 800
DAPQVLPGQL SVKLWYDKVG HQLIVNVLQA TDLPPRVDGR PRNPYVKMYF
810 820 830 840 850
LPDRSDKSKR RTKTVKKLLE PKWNQTFVYS HVHRRDFRER MLEITVWDQP
860 870 880 890 900
RVQDEESEFL GEILIELETA LLDDEPHWYK LQTHDESSLP LPQPSPFMPR
910 920 930 940 950
RHIHGESSSK KLQRSQRISD SDISDYEVDD GIGVVPPVGY RASARESKAT
960 970 980 990 1000
TLTVPEQQRT THHRSRSVSP HRGDDQGRPR SRLPNVPLQR SLDEIHPTRR
1010 1020 1030 1040 1050
SRSPTRHHDA SRSPADHRSR HVESQYSSEP DSELLMLPRA KRGRSAESLH
1060 1070 1080 1090 1100
MTSELQPSLD RARSASTNCL RPDTSLHSPE RERHSRKSER CSIQKQSRKG
1110 1120 1130 1140 1150
TASDADRVLP PCLSRRGYAT PRATDQPVVR GKYPTRSRSS EHSSVRTLCS
1160 1170 1180 1190 1200
MHHLAPGGSA PPSPLLLTRT HRQGSPTQSP PADTSFGSRR GRQLPQVPVR
1210 1220 1230 1240 1250
SGSIEQASLV VEERTRQMKV KVHRFKQTTG SGSSQELDHE QYSKYNIHKD
1260 1270 1280 1290 1300
QYRSCDNASA KSSDSDVSDV SAISRASSTS RLSSTSFMSE QSERPRGRIS
1310 1320 1330 1340 1350
SFTPKMQGRR MGTSGRAIIK STSVSGEIYT LERNDGSQSD TAVGTVGAGG
1360 1370 1380 1390 1400
KKRRSSLSAK VVAIVSRRSR STSQLSQTES GHKKLKSTIQ RSTETGMAAE
1410 1420 1430 1440 1450
MRKMVRQPSR ESTDGSINSY SSEGNLIFPG VRVGPDSQFS DFLDGLGPAQ
1460 1470 1480 1490 1500
LVGRQTLATP AMGDIQIGME DKKGQLEVEV IRARSLTQKP GSKSTPAPYV
1510 1520 1530 1540 1550
KVYLLENGAC IAKKKTRIAR KTLDPLYQQS LVFDESPQGK VLQVIVWGDY
1560 1570 1580 1590 1600
GRMDHKCFMG VAQILLEELD LSSMVIGWYK LFPPSSLVDP TLAPLTRRAS
1610
QSSLESSSGP PCIRS
Length:1,615
Mass (Da):179,655
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i80E76F74BF35FB7E
GO
Isoform 2 (identifier: Q9JIR4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1107-1168: Missing.

Show »
Length:1,553
Mass (Da):172,965
Checksum:iD6643997E65D03EE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JT77A0A0G2JT77_RAT
Regulating synaptic membrane exocyt...
Rims1
1,614Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1LYS1F1LYS1_RAT
Regulating synaptic membrane exocyt...
Rims1
1,553Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2KA18A0A0G2KA18_RAT
Regulating synaptic membrane exocyt...
Rims1
1,553Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2K708A0A0G2K708_RAT
Regulating synaptic membrane exocyt...
Rims1
1,613Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2KAV8A0A0G2KAV8_RAT
Regulating synaptic membrane exocyt...
Rims1
1,448Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0081721107 – 1168Missing in isoform 2. 1 PublicationAdd BLAST62

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF007836 mRNA Translation: AAB66703.1
AF199333 mRNA Translation: AAF81655.1

Protein sequence database of the Protein Information Resource

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PIRi
T03301

NCBI Reference Sequences

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RefSeqi
NP_439894.1, NM_052829.1 [Q9JIR4-2]

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
84556

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
rno:84556

UCSC genome browser

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UCSCi
RGD:620000 rat [Q9JIR4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007836 mRNA Translation: AAB66703.1
AF199333 mRNA Translation: AAF81655.1
PIRiT03301
RefSeqiNP_439894.1, NM_052829.1 [Q9JIR4-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZUBNMR-A597-705[»]
2Q3XX-ray1.73A/B1447-1615[»]
SMRiQ9JIR4
ModBaseiSearch...

Protein-protein interaction databases

BioGridi250003, 1 interactor
CORUMiQ9JIR4
DIPiDIP-41432N
ELMiQ9JIR4
IntActiQ9JIR4, 8 interactors
MINTiQ9JIR4
STRINGi10116.ENSRNOP00000015454

PTM databases

iPTMnetiQ9JIR4
PhosphoSitePlusiQ9JIR4

Proteomic databases

PRIDEiQ9JIR4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi84556
KEGGirno:84556
UCSCiRGD:620000 rat [Q9JIR4-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
22999
RGDi620000 Rims1

Phylogenomic databases

InParanoidiQ9JIR4
KOiK15291
OrthoDBi109268at2759
PhylomeDBiQ9JIR4

Enzyme and pathway databases

ReactomeiR-RNO-181429 Serotonin Neurotransmitter Release Cycle
R-RNO-181430 Norepinephrine Neurotransmitter Release Cycle
R-RNO-210500 Glutamate Neurotransmitter Release Cycle
R-RNO-212676 Dopamine Neurotransmitter Release Cycle
R-RNO-264642 Acetylcholine Neurotransmitter Release Cycle
R-RNO-888590 GABA synthesis, release, reuptake and degradation

Miscellaneous databases

EvolutionaryTraceiQ9JIR4

Protein Ontology

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PROi
PR:Q9JIR4

Family and domain databases

Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR041282 FYVE_2
IPR001478 PDZ
IPR036034 PDZ_sf
IPR010911 Rab_BD
IPR039032 Rim-like
IPR030630 RIM1
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
PANTHERiPTHR12157 PTHR12157, 2 hits
PTHR12157:SF19 PTHR12157:SF19, 2 hits
PfamiView protein in Pfam
PF00168 C2, 2 hits
PF02318 FYVE_2, 1 hit
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00239 C2, 2 hits
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits
PS50106 PDZ, 1 hit
PS50916 RABBD, 1 hit
PS50178 ZF_FYVE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRIMS1_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9JIR4
Secondary accession number(s): O35168
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: October 1, 2000
Last modified: May 8, 2019
This is version 153 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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