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Entry version 179 (31 Jul 2019)
Sequence version 1 (01 May 2000)
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Protein

Cathepsin Z

Gene

CTSZ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (PubMed:10504234). Capable of producing kinin potentiating peptides (By similarity).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

The disulfide bridge formed between Cys-33 in the propeptide and the active site residue Cys-92 may prevent activation of the zymogen through formation of a reversible covalent bond with the active site residue.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei922 Publications1
Active sitei2412 Publications1
Active sitei2612 Publications1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.4.18.1 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2022377 Metabolism of Angiotensinogen to Angiotensins
R-HSA-204005 COPII-mediated vesicle transport
R-HSA-432720 Lysosome Vesicle Biogenesis
R-HSA-5694530 Cargo concentration in the ER
R-HSA-6798695 Neutrophil degranulation

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C01.013

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cathepsin Z (EC:3.4.18.11 Publication)
Alternative name(s):
Cathepsin P
Cathepsin X
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CTSZ
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2547 CTSZ

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603169 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UBR2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1522

Open Targets

More...
OpenTargetsi
ENSG00000101160

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27043

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4160

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2354

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CTSZ

Domain mapping of disease mutations (DMDM)

More...
DMDMi
12643324

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002628524 – 61Activation peptideAdd BLAST38
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002628662 – 303Cathepsin ZAdd BLAST242

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi33 ↔ 92Combined sources1 Publication
Disulfide bondi89 ↔ 132Combined sources2 Publications
Disulfide bondi126 ↔ 164Combined sources2 Publications
Disulfide bondi154 ↔ 170Combined sources2 Publications
Disulfide bondi173 ↔ 179Combined sources2 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi184N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi214 ↔ 296Combined sources2 Publications
Glycosylationi224N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-53
CPTAC-54

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UBR2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UBR2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9UBR2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UBR2

PeptideAtlas

More...
PeptideAtlasi
Q9UBR2

PRoteomics IDEntifications database

More...
PRIDEi
Q9UBR2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
84036

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1082

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UBR2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UBR2

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9UBR2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000101160 Expressed in 200 organ(s), highest expression level in thoracic aorta

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9UBR2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB025114
HPA049876
HPA053504

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107902, 18 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UBR2, 25 interactors

Molecular INTeraction database

More...
MINTi
Q9UBR2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000217131

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9UBR2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1303
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UBR2

Database of comparative protein structure models

More...
ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9UBR2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1543 Eukaryota
COG4870 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155569

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000264454

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UBR2

KEGG Orthology (KO)

More...
KOi
K08568

Identification of Orthologs from Complete Genome Data

More...
OMAi
CTEFKEC

Database of Orthologous Groups

More...
OrthoDBi
1275401at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UBR2

TreeFam database of animal gene trees

More...
TreeFami
TF313225

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02698 Peptidase_C1A_CathepsinX, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR033157 CTSZ
IPR038765 Papain-like_cys_pep_sf
IPR025661 Pept_asp_AS
IPR000668 Peptidase_C1A_C

The PANTHER Classification System

More...
PANTHERi
PTHR12411:SF569 PTHR12411:SF569, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00112 Peptidase_C1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00705 PAPAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00645 Pept_C1, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF54001 SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00640 THIOL_PROTEASE_ASN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UBR2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARRGPGWRP LLLLVLLAGA AQGGLYFRRG QTCYRPLRGD GLAPLGRSTY
60 70 80 90 100
PRPHEYLSPA DLPKSWDWRN VDGVNYASIT RNQHIPQYCG SCWAHASTSA
110 120 130 140 150
MADRINIKRK GAWPSTLLSV QNVIDCGNAG SCEGGNDLSV WDYAHQHGIP
160 170 180 190 200
DETCNNYQAK DQECDKFNQC GTCNEFKECH AIRNYTLWRV GDYGSLSGRE
210 220 230 240 250
KMMAEIYANG PISCGIMATE RLANYTGGIY AEYQDTTYIN HVVSVAGWGI
260 270 280 290 300
SDGTEYWIVR NSWGEPWGER GWLRIVTSTY KDGKGARYNL AIEEHCTFGD

PIV
Length:303
Mass (Da):33,868
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6274FD1974D0EBDC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti48S → T in AAC39839 (PubMed:9642240).Curated1
Sequence conflicti150P → S in AAC61477 (PubMed:9738465).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01025436P → S1 PublicationCorresponds to variant dbSNP:rs778998634Ensembl.1
Natural variantiVAR_010255129A → R Requires 2 nucleotide substitutions. 1 Publication1
Natural variantiVAR_033719286A → T. Corresponds to variant dbSNP:rs34069356Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF073890 mRNA Translation: AAC61477.1
AF032906 mRNA Translation: AAC39839.1
AF136273 mRNA Translation: AAF13145.1
AF136276, AF136274, AF136275 Genomic DNA Translation: AAF13148.1
AK314931 mRNA Translation: BAG37437.1
AL109840 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75448.1
BC042168 mRNA Translation: AAH42168.1
AF009923 mRNA Translation: AAC63141.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13474.1

NCBI Reference Sequences

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RefSeqi
NP_001327.2, NM_001336.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000217131; ENSP00000217131; ENSG00000101160

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1522

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1522

UCSC genome browser

More...
UCSCi
uc002yai.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF073890 mRNA Translation: AAC61477.1
AF032906 mRNA Translation: AAC39839.1
AF136273 mRNA Translation: AAF13145.1
AF136276, AF136274, AF136275 Genomic DNA Translation: AAF13148.1
AK314931 mRNA Translation: BAG37437.1
AL109840 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75448.1
BC042168 mRNA Translation: AAH42168.1
AF009923 mRNA Translation: AAC63141.1
CCDSiCCDS13474.1
RefSeqiNP_001327.2, NM_001336.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DEUX-ray1.70A/B27-303[»]
1EF7X-ray2.67A/B62-303[»]
SMRiQ9UBR2
ModBaseiSearch...

Protein-protein interaction databases

BioGridi107902, 18 interactors
IntActiQ9UBR2, 25 interactors
MINTiQ9UBR2
STRINGi9606.ENSP00000217131

Chemistry databases

BindingDBiQ9UBR2
ChEMBLiCHEMBL4160
GuidetoPHARMACOLOGYi2354

Protein family/group databases

MEROPSiC01.013

PTM databases

GlyConnecti1082
iPTMnetiQ9UBR2
PhosphoSitePlusiQ9UBR2
SwissPalmiQ9UBR2

Polymorphism and mutation databases

BioMutaiCTSZ
DMDMi12643324

Proteomic databases

CPTACiCPTAC-53
CPTAC-54
EPDiQ9UBR2
jPOSTiQ9UBR2
MaxQBiQ9UBR2
PaxDbiQ9UBR2
PeptideAtlasiQ9UBR2
PRIDEiQ9UBR2
ProteomicsDBi84036

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1522
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000217131; ENSP00000217131; ENSG00000101160
GeneIDi1522
KEGGihsa:1522
UCSCiuc002yai.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1522
DisGeNETi1522

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CTSZ
HGNCiHGNC:2547 CTSZ
HPAiCAB025114
HPA049876
HPA053504
MIMi603169 gene
neXtProtiNX_Q9UBR2
OpenTargetsiENSG00000101160
PharmGKBiPA27043

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1543 Eukaryota
COG4870 LUCA
GeneTreeiENSGT00940000155569
HOGENOMiHOG000264454
InParanoidiQ9UBR2
KOiK08568
OMAiCTEFKEC
OrthoDBi1275401at2759
PhylomeDBiQ9UBR2
TreeFamiTF313225

Enzyme and pathway databases

BRENDAi3.4.18.1 2681
ReactomeiR-HSA-2022377 Metabolism of Angiotensinogen to Angiotensins
R-HSA-204005 COPII-mediated vesicle transport
R-HSA-432720 Lysosome Vesicle Biogenesis
R-HSA-5694530 Cargo concentration in the ER
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CTSZ human
EvolutionaryTraceiQ9UBR2

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Cathepsin_Z

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1522

Protein Ontology

More...
PROi
PR:Q9UBR2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
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Gene expression databases

BgeeiENSG00000101160 Expressed in 200 organ(s), highest expression level in thoracic aorta
GenevisibleiQ9UBR2 HS

Family and domain databases

CDDicd02698 Peptidase_C1A_CathepsinX, 1 hit
InterProiView protein in InterPro
IPR033157 CTSZ
IPR038765 Papain-like_cys_pep_sf
IPR025661 Pept_asp_AS
IPR000668 Peptidase_C1A_C
PANTHERiPTHR12411:SF569 PTHR12411:SF569, 1 hit
PfamiView protein in Pfam
PF00112 Peptidase_C1, 1 hit
PRINTSiPR00705 PAPAIN
SMARTiView protein in SMART
SM00645 Pept_C1, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00640 THIOL_PROTEASE_ASN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCATZ_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UBR2
Secondary accession number(s): B2RC40
, O75331, Q9UQV5, Q9UQV6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 2000
Last modified: July 31, 2019
This is version 179 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. Peptidase families
    Classification of peptidase families and list of entries
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