| http://purl.uniprot.org/citations/17940011 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17940011 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Citation |
| http://purl.uniprot.org/citations/17940011 | http://www.w3.org/2000/01/rdf-schema#comment | "A recently discovered phosphatidylinositol monophosphate, phosphatidylinositol 5-phosphate (PtdIns-5-P), plays an important role in nuclear signaling by influencing p53-dependent apoptosis. It interacts with a plant homeodomain finger of inhibitor of growth protein-2, causing an increase in the acetylation and stability of p53. Here we show that type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase (type I 4-phosphatase), an enzyme that dephosphorylates phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P(2)), forming PtdIns-5-P in vitro, can increase the cellular levels of PtdIns-5-P. When HeLa cells were treated with the DNA-damaging agents etoposide or doxorubicin, type I 4-phosphatase translocated to the nucleus and nuclear levels of PtdIns-5-P increased. This action resulted in increased p53 acetylation, which stabilized p53, leading to increased apoptosis. Overexpression of type I 4-phosphatase increased apoptosis, whereas RNAi of the enzyme diminished it. The half-life of p53 was shortened from 7 h to 1.8 h upon RNAi of type I 4-phosphatase. This enzyme therefore controls nuclear levels of PtdIns-5-P and thereby p53-dependent apoptosis."xsd:string |
| http://purl.uniprot.org/citations/17940011 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0708189104"xsd:string |
| http://purl.uniprot.org/citations/17940011 | http://purl.uniprot.org/core/author | "Zou J."xsd:string |
| http://purl.uniprot.org/citations/17940011 | http://purl.uniprot.org/core/author | "Majerus P.W."xsd:string |
| http://purl.uniprot.org/citations/17940011 | http://purl.uniprot.org/core/author | "Wilson M."xsd:string |
| http://purl.uniprot.org/citations/17940011 | http://purl.uniprot.org/core/author | "Kisseleva M.V."xsd:string |
| http://purl.uniprot.org/citations/17940011 | http://purl.uniprot.org/core/author | "Marjanovic J."xsd:string |
| http://purl.uniprot.org/citations/17940011 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17940011 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/17940011 | http://purl.uniprot.org/core/pages | "16834-16839"xsd:string |
| http://purl.uniprot.org/citations/17940011 | http://purl.uniprot.org/core/title | "Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis."xsd:string |
| http://purl.uniprot.org/citations/17940011 | http://purl.uniprot.org/core/volume | "104"xsd:string |
| http://purl.uniprot.org/citations/17940011 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17940011 |
| http://purl.uniprot.org/citations/17940011 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17940011 |
| http://purl.uniprot.org/citations/17940011 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17940011 |
| http://purl.uniprot.org/citations/17940011 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17940011 |
| http://purl.uniprot.org/enzyme/3.1.3.78 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/17940011 |
| http://purl.uniprot.org/uniprot/#_Q86T03-mappedCitation-17940011 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17940011 |
| http://purl.uniprot.org/uniprot/#_P04637-mappedCitation-17940011 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17940011 |
| http://purl.uniprot.org/uniprot/#_Q09472-mappedCitation-17940011 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17940011 |
| http://purl.uniprot.org/uniprot/#_Q9H160-mappedCitation-17940011 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17940011 |
| http://purl.uniprot.org/uniprot/Q09472 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17940011 |
| http://purl.uniprot.org/uniprot/Q9H160 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17940011 |