http://purl.uniprot.org/enzyme/2.7.11.24 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Enzyme |
http://purl.uniprot.org/enzyme/2.7.11.24 | http://www.w3.org/2000/01/rdf-schema#subClassOf | http://purl.uniprot.org/enzyme/2.7.11.- |
http://purl.uniprot.org/enzyme/2.7.11.24 | http://www.w3.org/2000/01/rdf-schema#subClassOf | http://purl.uniprot.org/enzyme/2.7.-.- |
http://purl.uniprot.org/enzyme/2.7.11.24 | http://www.w3.org/2000/01/rdf-schema#subClassOf | http://purl.uniprot.org/enzyme/2.-.-.- |
http://purl.uniprot.org/enzyme/2.7.11.24 | http://www.w3.org/2000/01/rdf-schema#subClassOf | http://purl.uniprot.org/core/Enzyme |
http://purl.uniprot.org/enzyme/2.7.11.24 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation."xsd:string |
http://purl.uniprot.org/enzyme/2.7.11.24 | http://www.w3.org/2000/01/rdf-schema#comment | "Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumor necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischemeic injury."xsd:string |
http://purl.uniprot.org/enzyme/2.7.11.24 | http://www.w3.org/2000/01/rdf-schema#comment | "Phosphorylation of specific tyrosine and threonine residues in the activation loop of this enzyme by EC 2.7.12.2 is necessary for enzyme activation."xsd:string |
http://purl.uniprot.org/enzyme/2.7.11.24 | http://www.w3.org/2000/01/rdf-schema#comment | "Once activated, the enzyme phosphorylates target substrates on serine or threonine residues followed by a proline."xsd:string |
http://purl.uniprot.org/enzyme/2.7.11.24 | http://www.w3.org/2000/01/rdf-schema#comment | "A distinguishing feature of all MAPKs is the conserved sequence Thr-Xaa-Tyr (TXY)."xsd:string |
http://purl.uniprot.org/enzyme/2.7.11.24 | http://www.w3.org/2004/02/skos/core#prefLabel | "mitogen-activated protein kinase"xsd:string |
http://purl.uniprot.org/enzyme/2.7.11.24 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/10715136 |
http://purl.uniprot.org/enzyme/2.7.11.24 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/9235954 |
http://purl.uniprot.org/enzyme/2.7.11.24 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/1321146 |
http://purl.uniprot.org/enzyme/2.7.11.24 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/15187187 |
http://purl.uniprot.org/enzyme/2.7.11.24 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/1657919 |
http://purl.uniprot.org/enzyme/2.7.11.24 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/2842341 |
http://purl.uniprot.org/enzyme/2.7.11.24 | http://www.w3.org/2004/02/skos/core#altLabel | "MAP kinase"xsd:string |
http://purl.uniprot.org/enzyme/2.7.11.24 | http://www.w3.org/2004/02/skos/core#altLabel | "MAPK"xsd:string |
http://purl.uniprot.org/enzyme/2.7.11.24 | http://www.w3.org/2004/02/skos/core#altLabel | "JNK"xsd:string |
http://purl.uniprot.org/enzyme/2.7.11.24 | http://www.w3.org/2004/02/skos/core#altLabel | "ERK"xsd:string |
http://purl.uniprot.org/enzyme/2.7.11.24 | http://www.w3.org/2004/02/skos/core#altLabel | "extracellular signal-regulated kinase"xsd:string |
http://purl.uniprot.org/enzyme/2.7.11.24 | http://www.w3.org/2004/02/skos/core#altLabel | "c-Jun N-terminal kinase"xsd:string |
http://purl.uniprot.org/enzyme/2.7.11.24 | http://www.w3.org/2004/02/skos/core#altLabel | "SAPK"xsd:string |
http://purl.uniprot.org/enzyme/2.7.11.24 | http://www.w3.org/2004/02/skos/core#altLabel | "MBP kinase I"xsd:string |