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http://purl.uniprot.org/enzyme/2.7.11.24http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Enzyme
http://purl.uniprot.org/enzyme/2.7.11.24http://www.w3.org/2000/01/rdf-schema#subClassOfhttp://purl.uniprot.org/enzyme/2.7.11.-
http://purl.uniprot.org/enzyme/2.7.11.24http://www.w3.org/2000/01/rdf-schema#subClassOfhttp://purl.uniprot.org/enzyme/2.7.-.-
http://purl.uniprot.org/enzyme/2.7.11.24http://www.w3.org/2000/01/rdf-schema#subClassOfhttp://purl.uniprot.org/enzyme/2.-.-.-
http://purl.uniprot.org/enzyme/2.7.11.24http://www.w3.org/2000/01/rdf-schema#subClassOfhttp://purl.uniprot.org/core/Enzyme
http://purl.uniprot.org/enzyme/2.7.11.24http://www.w3.org/2000/01/rdf-schema#comment"Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation."xsd:string
http://purl.uniprot.org/enzyme/2.7.11.24http://www.w3.org/2000/01/rdf-schema#comment"Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumor necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischemeic injury."xsd:string
http://purl.uniprot.org/enzyme/2.7.11.24http://www.w3.org/2000/01/rdf-schema#comment"Phosphorylation of specific tyrosine and threonine residues in the activation loop of this enzyme by EC 2.7.12.2 is necessary for enzyme activation."xsd:string
http://purl.uniprot.org/enzyme/2.7.11.24http://www.w3.org/2000/01/rdf-schema#comment"Once activated, the enzyme phosphorylates target substrates on serine or threonine residues followed by a proline."xsd:string
http://purl.uniprot.org/enzyme/2.7.11.24http://www.w3.org/2000/01/rdf-schema#comment"A distinguishing feature of all MAPKs is the conserved sequence Thr-Xaa-Tyr (TXY)."xsd:string
http://purl.uniprot.org/enzyme/2.7.11.24http://www.w3.org/2004/02/skos/core#prefLabel"mitogen-activated protein kinase"xsd:string
http://purl.uniprot.org/enzyme/2.7.11.24http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/10715136
http://purl.uniprot.org/enzyme/2.7.11.24http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/9235954
http://purl.uniprot.org/enzyme/2.7.11.24http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/1321146
http://purl.uniprot.org/enzyme/2.7.11.24http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/15187187
http://purl.uniprot.org/enzyme/2.7.11.24http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/1657919
http://purl.uniprot.org/enzyme/2.7.11.24http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/2842341
http://purl.uniprot.org/enzyme/2.7.11.24http://www.w3.org/2004/02/skos/core#altLabel"MAP kinase"xsd:string
http://purl.uniprot.org/enzyme/2.7.11.24http://www.w3.org/2004/02/skos/core#altLabel"MAPK"xsd:string
http://purl.uniprot.org/enzyme/2.7.11.24http://www.w3.org/2004/02/skos/core#altLabel"JNK"xsd:string
http://purl.uniprot.org/enzyme/2.7.11.24http://www.w3.org/2004/02/skos/core#altLabel"ERK"xsd:string
http://purl.uniprot.org/enzyme/2.7.11.24http://www.w3.org/2004/02/skos/core#altLabel"extracellular signal-regulated kinase"xsd:string
http://purl.uniprot.org/enzyme/2.7.11.24http://www.w3.org/2004/02/skos/core#altLabel"c-Jun N-terminal kinase"xsd:string
http://purl.uniprot.org/enzyme/2.7.11.24http://www.w3.org/2004/02/skos/core#altLabel"SAPK"xsd:string
http://purl.uniprot.org/enzyme/2.7.11.24http://www.w3.org/2004/02/skos/core#altLabel"MBP kinase I"xsd:string