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Entry version 166 (18 Sep 2019)
Sequence version 2 (08 Nov 2005)
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Protein

Tenascin-N

Gene

TNN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Extracellular matrix protein that seems to be a ligand for ITGA8:ITGB1, ITGAV:ITGB1 and ITGA4:ITGB1 (By similarity) (PubMed:17909022). Involved in neurite outgrowth and cell migration in hippocampal explants (By similarity). During endochondral bone formation, inhibits proliferation and differentiation of proteoblasts mediated by canonical WNT signaling (By similarity). In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327). Expressed in most mammary tumors, may facilitate tumorigenesis by supporting the migratory behavior of breast cancer cells (PubMed:17909022).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3000178 ECM proteoglycans

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tenascin-NImported
Short name:
TN-N
Alternative name(s):
Tenascin-W1 Publication
Short name:
TN-W
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNNImported
Synonyms:TNW1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:22942 TNN

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617472 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UQP3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
63923

Open Targets

More...
OpenTargetsi
ENSG00000120332

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134973710

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TNN

Domain mapping of disease mutations (DMDM)

More...
DMDMi
81175198

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Sequence analysisAdd BLAST28
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000774529 – 1299Tenascin-NAdd BLAST1271

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi171 ↔ 181PROSITE-ProRule annotation
Disulfide bondi175 ↔ 186PROSITE-ProRule annotation
Disulfide bondi188 ↔ 197PROSITE-ProRule annotation
Disulfide bondi202 ↔ 212PROSITE-ProRule annotation
Disulfide bondi206 ↔ 217PROSITE-ProRule annotation
Disulfide bondi219 ↔ 228PROSITE-ProRule annotation
Disulfide bondi233 ↔ 243PROSITE-ProRule annotation
Disulfide bondi237 ↔ 248PROSITE-ProRule annotation
Disulfide bondi250 ↔ 259PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi1149N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UQP3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UQP3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UQP3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UQP3

PeptideAtlas

More...
PeptideAtlasi
Q9UQP3

PRoteomics IDEntifications database

More...
PRIDEi
Q9UQP3

ProteomicsDB human proteome resource

More...
ProteomicsDBi
85562

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1793

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UQP3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UQP3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Not detected in normal adult mammary tissues or brain but expressed in most breast tumors and brain tumors, such as glioblastomas, astrocytomas and oligodendrogliomas, tested (PubMed:17909022, PubMed:19884327). In brain tumors, detected around the endothelial cell layer of the clood vessels (PubMed:19884327).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000120332 Expressed in 74 organ(s), highest expression level in periodontal ligament

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9UQP3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UQP3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB010907
HPA026726
HPA026764

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homohexamer.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121992, 4 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1012 Tenascin-W complex

Protein interaction database and analysis system

More...
IntActi
Q9UQP3, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000239462

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UQP3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini167 – 198EGF-like 1Add BLAST32
Domaini199 – 229EGF-like 2Add BLAST31
Domaini230 – 260EGF-like 3Add BLAST31
Domaini264 – 352Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST89
Domaini353 – 444Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST92
Domaini445 – 532Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST88
Domaini533 – 623Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST91
Domaini624 – 709Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST86
Domaini710 – 800Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST91
Domaini801 – 886Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST86
Domaini887 – 976Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST90
Domaini977 – 1063Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST87
Domaini1061 – 1278Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST218

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tenascin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1225 Eukaryota
KOG2579 Eukaryota
ENOG410ZYS4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160553

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234355

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UQP3

KEGG Orthology (KO)

More...
KOi
K06252

Identification of Orthologs from Complete Genome Data

More...
OMAi
APIDRYM

Database of Orthologous Groups

More...
OrthoDBi
18592at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UQP3

TreeFam database of animal gene trees

More...
TreeFami
TF329915

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 9 hits
cd00087 FReD, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 9 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR041161 EGF_Tenascin
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR020837 Fibrinogen_CS
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18720 EGF_Tenascin, 1 hit
PF00147 Fibrinogen_C, 1 hit
PF00041 fn3, 9 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 3 hits
SM00186 FBG, 1 hit
SM00060 FN3, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 5 hits
SSF56496 SSF56496, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 3 hits
PS01186 EGF_2, 2 hits
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit
PS50853 FN3, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9UQP3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLQEMFRFP MGLLLGSVLL VASAPATLEP PGCSNKEQQV TVSHTYKIDV
60 70 80 90 100
PKSALVQVDA DPQPLSDDGA SLLALGEARE EQNIIFRHNI RLQTPQKDCE
110 120 130 140 150
LAGSVQDLLA RVKKLEEEMV EMKEQCSAQR CCQGVTDLSR HCSGHGTFSL
160 170 180 190 200
ETCSCHCEEG REGPACERLA CPGACSGHGR CVDGRCLCHE PYVGADCGYP
210 220 230 240 250
ACPENCSGHG ECVRGVCQCH EDFMSEDCSE KRCPGDCSGH GFCDTGECYC
260 270 280 290 300
EEGFTGLDCA QVVTPQGLQL LKNTEDSLLV SWEPSSQVDH YLLSYYPLGK
310 320 330 340 350
ELSGKQIQVP KEQHSYEILG LLPGTKYIVT LRNVKNEVSS SPQHLLATTD
360 370 380 390 400
LAVLGTAWVT DETENSLDVE WENPSTEVDY YKLRYGPMTG QEVAEVTVPK
410 420 430 440 450
SSDPKSRYDI TGLHPGTEYK ITVVPMRGEL EGKPILLNGR TEIDSPTNVV
460 470 480 490 500
TDRVTEDTAT VSWDPVQAVI DKYVVRYTSA DGDTKEMAVH KDESSTVLTG
510 520 530 540 550
LKPGEAYKVY VWAERGNQGS KKADTNALTE IDSPANLVTD RVTENTATIS
560 570 580 590 600
WDPVQATIDK YVVRYTSADD QETREVLVGK EQSSTVLTGL RPGVEYTVHV
610 620 630 640 650
WAQKGDRESK KADTNAPTDI DSPKNLVTDR VTENMATVSW DPVQAAIDKY
660 670 680 690 700
VVRYTSAGGE TREVPVGKEQ SSTVLTGLRP GMEYMVHVWA QKGDQESKKA
710 720 730 740 750
DTKAQTDIDS PQNLVTDRVT ENMATVSWDP VRATIDRYVV RYTSAKDGET
760 770 780 790 800
REVPVGKEQS STVLTGLRPG VEYTVHVWAQ KGAQESKKAD TKAQTDIDSP
810 820 830 840 850
QNLVTDWVTE NTATVSWDPV QATIDRYVVH YTSANGETRE VPVGKEQSST
860 870 880 890 900
VLTGLRPGME YTVHVWAQKG NQESKKADTK AQTEIDGPKN LVTDWVTENM
910 920 930 940 950
ATVSWDPVQA TIDKYMVRYT SADGETREVP VGKEHSSTVL TGLRPGMEYM
960 970 980 990 1000
VHVWAQKGAQ ESKKADTKAQ TELDPPRNLR PSAVTQSGGI LTWTPPSAQI
1010 1020 1030 1040 1050
HGYILTYQFP DGTVKEMQLG REDQRFALQG LEQGATYPVS LVAFKGGRRS
1060 1070 1080 1090 1100
RNVSTTLSTV GARFPHPSDC SQVQQNSNAA SGLYTIYLHG DASRPLQVYC
1110 1120 1130 1140 1150
DMETDGGGWI VFQRRNTGQL DFFKRWRSYV EGFGDPMKEF WLGLDKLHNL
1160 1170 1180 1190 1200
TTGTPARYEV RVDLQTANES AYAIYDFFQV ASSKERYKLT VGKYRGTAGD
1210 1220 1230 1240 1250
ALTYHNGWKF TTFDRDNDIA LSNCALTHHG GWWYKNCHLA NPNGRYGETK
1260 1270 1280 1290
HSEGVNWEPW KGHEFSIPYV ELKIRPHGYS REPVLGRKKR TLRGRLRTF
Length:1,299
Mass (Da):144,034
Last modified:November 8, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCC4BBD5CE47ADBED
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WXT0A0A087WXT0_HUMAN
Tenascin-N
TNN
1,122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WXC4A0A087WXC4_HUMAN
Tenascin-N
TNN
1,122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04900779R → G. Corresponds to variant dbSNP:rs2072032Ensembl.1
Natural variantiVAR_033832289D → N. Corresponds to variant dbSNP:rs16847812Ensembl.1
Natural variantiVAR_049008440R → S. Corresponds to variant dbSNP:rs6664276Ensembl.1
Natural variantiVAR_033833499T → M. Corresponds to variant dbSNP:rs17374761Ensembl.1
Natural variantiVAR_033834807W → R. Corresponds to variant dbSNP:rs6696455Ensembl.1
Natural variantiVAR_059275859M → V. Corresponds to variant dbSNP:rs6694078Ensembl.1
Natural variantiVAR_024269930P → L. Corresponds to variant dbSNP:rs2285215Ensembl.1
Natural variantiVAR_033835941T → M. Corresponds to variant dbSNP:rs10798333Ensembl.1
Natural variantiVAR_0490091135D → E. Corresponds to variant dbSNP:rs10158841Ensembl.1
Natural variantiVAR_0490101156A → V. Corresponds to variant dbSNP:rs2072036Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z99297 Genomic DNA No translation available.
Z99715 Genomic DNA No translation available.
BC136619 mRNA Translation: AAI36620.1
AL049689 mRNA Translation: CAB41260.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS30943.1

NCBI Reference Sequences

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RefSeqi
NP_071376.1, NM_022093.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
63923

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:63923

UCSC genome browser

More...
UCSCi
uc001gkl.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z99297 Genomic DNA No translation available.
Z99715 Genomic DNA No translation available.
BC136619 mRNA Translation: AAI36620.1
AL049689 mRNA Translation: CAB41260.1
CCDSiCCDS30943.1
RefSeqiNP_071376.1, NM_022093.1

3D structure databases

SMRiQ9UQP3
ModBaseiSearch...

Protein-protein interaction databases

BioGridi121992, 4 interactors
ComplexPortaliCPX-1012 Tenascin-W complex
IntActiQ9UQP3, 1 interactor
STRINGi9606.ENSP00000239462

PTM databases

GlyConnecti1793
iPTMnetiQ9UQP3
PhosphoSitePlusiQ9UQP3

Polymorphism and mutation databases

BioMutaiTNN
DMDMi81175198

Proteomic databases

EPDiQ9UQP3
jPOSTiQ9UQP3
MassIVEiQ9UQP3
PaxDbiQ9UQP3
PeptideAtlasiQ9UQP3
PRIDEiQ9UQP3
ProteomicsDBi85562

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi63923
KEGGihsa:63923
UCSCiuc001gkl.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
63923
DisGeNETi63923

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TNN
HGNCiHGNC:22942 TNN
HPAiCAB010907
HPA026726
HPA026764
MIMi617472 gene
neXtProtiNX_Q9UQP3
OpenTargetsiENSG00000120332
PharmGKBiPA134973710

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1225 Eukaryota
KOG2579 Eukaryota
ENOG410ZYS4 LUCA
GeneTreeiENSGT00940000160553
HOGENOMiHOG000234355
InParanoidiQ9UQP3
KOiK06252
OMAiAPIDRYM
OrthoDBi18592at2759
PhylomeDBiQ9UQP3
TreeFamiTF329915

Enzyme and pathway databases

ReactomeiR-HSA-3000178 ECM proteoglycans

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TNN human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
63923

Pharos

More...
Pharosi
Q9UQP3

Protein Ontology

More...
PROi
PR:Q9UQP3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000120332 Expressed in 74 organ(s), highest expression level in periodontal ligament
ExpressionAtlasiQ9UQP3 baseline and differential
GenevisibleiQ9UQP3 HS

Family and domain databases

CDDicd00063 FN3, 9 hits
cd00087 FReD, 1 hit
Gene3Di2.60.40.10, 9 hits
InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR041161 EGF_Tenascin
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR020837 Fibrinogen_CS
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF18720 EGF_Tenascin, 1 hit
PF00147 Fibrinogen_C, 1 hit
PF00041 fn3, 9 hits
SMARTiView protein in SMART
SM00181 EGF, 3 hits
SM00186 FBG, 1 hit
SM00060 FN3, 9 hits
SUPFAMiSSF49265 SSF49265, 5 hits
SSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 3 hits
PS01186 EGF_2, 2 hits
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit
PS50853 FN3, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTENN_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UQP3
Secondary accession number(s): A0A0A6YY94, B9EGP3, Q5R360
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: November 8, 2005
Last modified: September 18, 2019
This is version 166 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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