| http://purl.uniprot.org/enzyme/6.2.1.64 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Enzyme |
| http://purl.uniprot.org/enzyme/6.2.1.64 | http://www.w3.org/2000/01/rdf-schema#subClassOf | http://purl.uniprot.org/enzyme/6.-.-.- |
| http://purl.uniprot.org/enzyme/6.2.1.64 | http://www.w3.org/2000/01/rdf-schema#subClassOf | http://purl.uniprot.org/enzyme/6.2.-.- |
| http://purl.uniprot.org/enzyme/6.2.1.64 | http://www.w3.org/2000/01/rdf-schema#subClassOf | http://purl.uniprot.org/enzyme/6.2.1.- |
| http://purl.uniprot.org/enzyme/6.2.1.64 | http://www.w3.org/2000/01/rdf-schema#subClassOf | http://purl.uniprot.org/core/Enzyme |
| http://purl.uniprot.org/enzyme/6.2.1.64 | http://www.w3.org/2000/01/rdf-schema#comment | "The cullin protein needs to be activated by the ubiquitin-like protein NEDD8 in a process known as neddylation."xsd:string |
| http://purl.uniprot.org/enzyme/6.2.1.64 | http://www.w3.org/2000/01/rdf-schema#comment | "Some RING-type E3 ubiquitin transferase (EC 2.3.2.27) are not able to bind a substrate protein directly."xsd:string |
| http://purl.uniprot.org/enzyme/6.2.1.64 | http://www.w3.org/2000/01/rdf-schema#comment | "The activated NEDD8 is subsequently transferred to a cysteine residue of EC 2.3.2.34, and is eventually conjugated to a lysine residue of specific substrates in the presence of the appropriate E3 transferase (EC 2.3.2.32)."xsd:string |
| http://purl.uniprot.org/enzyme/6.2.1.64 | http://www.w3.org/2000/01/rdf-schema#comment | "Like ubiquitin, the NEDD8 protein ends with two glycine residues."xsd:string |
| http://purl.uniprot.org/enzyme/6.2.1.64 | http://www.w3.org/2000/01/rdf-schema#comment | "The E1 NEDD8-activating enzyme activates NEDD8 in an ATP-dependent reaction by forming a high-energy thioester intermediate between NEDD8 and one of its cysteine residues."xsd:string |
| http://purl.uniprot.org/enzyme/6.2.1.64 | http://www.w3.org/2000/01/rdf-schema#comment | "Instead, they form complexes with a cullin scaffold protein and a substrate recognition module, which are known as CRL (Cullin-RING-Ligase) complexes."xsd:string |
| http://purl.uniprot.org/enzyme/6.2.1.64 | http://www.w3.org/2004/02/skos/core#prefLabel | "E1 NEDD8-activating enzyme"xsd:string |
| http://purl.uniprot.org/enzyme/6.2.1.64 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/9694792 |
| http://purl.uniprot.org/enzyme/6.2.1.64 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/10207026 |
| http://purl.uniprot.org/enzyme/6.2.1.64 | http://www.w3.org/2004/02/skos/core#altLabel | "NEDD-activating enzyme E1"xsd:string |
| http://purl.uniprot.org/enzyme/6.2.1.64 | http://purl.uniprot.org/core/activity | http://purl.uniprot.org/enzyme/6.2.1.64#SIPB47299EB42597277 |
| http://purl.uniprot.org/enzyme/6.2.1.64 | http://www.w3.org/2004/02/skos/core#broaderTransitive | http://purl.uniprot.org/enzyme/6.2.1.- |
| http://purl.uniprot.org/uniprot/A0A7S3W2G4 | http://purl.uniprot.org/core/enzyme | http://purl.uniprot.org/enzyme/6.2.1.64 |
| http://purl.uniprot.org/uniprot/A0A9P5E6Y4 | http://purl.uniprot.org/core/enzyme | http://purl.uniprot.org/enzyme/6.2.1.64 |
| http://purl.uniprot.org/uniprot/A0AA35NNN0 | http://purl.uniprot.org/core/enzyme | http://purl.uniprot.org/enzyme/6.2.1.64 |
| http://purl.uniprot.org/uniprot/A0A835U1U5 | http://purl.uniprot.org/core/enzyme | http://purl.uniprot.org/enzyme/6.2.1.64 |
| http://purl.uniprot.org/uniprot/A0A835G0J3 | http://purl.uniprot.org/core/enzyme | http://purl.uniprot.org/enzyme/6.2.1.64 |
| http://purl.uniprot.org/uniprot/A0AA39I6N1 | http://purl.uniprot.org/core/enzyme | http://purl.uniprot.org/enzyme/6.2.1.64 |
| http://purl.uniprot.org/uniprot/A0A9P6D4S9 | http://purl.uniprot.org/core/enzyme | http://purl.uniprot.org/enzyme/6.2.1.64 |
| http://purl.uniprot.org/uniprot/A0A8D3E2U1 | http://purl.uniprot.org/core/enzyme | http://purl.uniprot.org/enzyme/6.2.1.64 |